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Enos Gene Glu298asp Variant Confer Risk in Sudden Sensorineural Hearing Loss Publisher Pubmed



Yazdani N1 ; Kakavand Hamidi A2 ; Soroush N2 ; Jalili N3 ; Vahidi A2 ; Zarabi Ahrabi N3 ; Tajdini A1 ; Amoli M2
Authors
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Authors Affiliations
  1. 1. Department of Otolaryngology–Head and Neck Surgery, Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biology, Islamic Azad University of Medical Sciences, Tehran, Iran

Source: Acta Oto-Laryngologica Published:2018


Abstract

Background: Sudden sensorineural hearing loss (SSNHL) causes the loss of hearing of 30 dB or greater on at least three contiguous frequencies. It is known to be a multifactorial disease which the exact cause is unknown, rendering it as an idiopathic disorder of patients. Aims/objectives: This study aims to shed further light on pathogenesis of this disease by studying the association between eNOS gene Glu298Asp polymorphism and VDR gene FokI polymorphism with SSNHL in Iranian population. Material and methods: This study involves a total of 77 cases and 100 controls, with patients inflicted with SSNHL categorized in case group and healthy subjects as control group. Genotyping of the VDR and eNOS genes was conducted by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. Results: Our results showed a statistically significant association between genotype frequencies of eNOS gene Glu298Asp polymorphism in case group compared to healthy individuals in the control group (p =.01). Also, TT genotype was significantly the most prevalent genotype in case group in comparison to control group (TT vs GT + GG, OR = 3.5; 95% CI = 1.18–11.79). On the other hand, analysis of VDR gene FokI polymorphism frequencies showed no statistically significant association with SSNHL. Conclusions and significance: Our findings showed a significant association between the eNOS gene Glu298Asp polymorphism and SSNHL in the Iranian population; and “TT” genotype might be considered as a risk factor for SSNHL. © 2018, © 2018 Acta Oto-Laryngologica AB (Ltd).
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