Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water

Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water Publisher

Sayahi MH¹ ; Shamkhani F¹ ; Mahdavi M² ; Bahadorikhalili S²

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1. Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran
2. Endocrinology and Metabolism Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Research on Chemical Intermediates Published:2021

Abstract

10-Methyl-7-aryl-7,12-dihydro-6H,8H-chromeno[4,3-b]pyrano[3,4-e]pyridine-6,8-dione derivatives are significant class of compounds and this is critical to develop methods in water using commercially available and non-toxic catalysts. In this paper, an efficient method is introduced for the synthesis of 10-methyl-7-aryl-7,12-dihydro-6H,8H-chromeno[4,3-b]pyrano[3,4-e]pyridine-6,8-dione derivatives. For the synthesis of the desired products, a multicomponent reaction was designed and performed between 4-hydroxycoumarin, an aldehyde, 6-methyl-2H-pyran-2,4(3H)-dione, and ammonium acetate. The products are obtained under green conditions in water in the presence of a catalytic amount of L-proline (10 mol%). The advantage of this method is no need to any toxic solvent, which is critical from the environmental viewpoint. A possible mechanism was suggested, which confirms the role of L-proline in the reaction as the catalyst. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.

Style	Citing Format
MLA	Sayahi MH, et al.. "Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water." Research on Chemical Intermediates, vol. 47, no. 10, 2021, pp. 4101-4112.
APA	Sayahi MH, Shamkhani F, Mahdavi M, Bahadorikhalili S (2021). Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water. Research on Chemical Intermediates, 47(10), 4101-4112.
Chicago	Sayahi MH, Shamkhani F, Mahdavi M, Bahadorikhalili S. "Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water." Research on Chemical Intermediates 47, no. 10 (2021): 4101-4112.
Harvard	Sayahi MH et al. (2021) 'Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water', Research on Chemical Intermediates, 47(10), pp. 4101-4112.
Vancouver	Sayahi MH, Shamkhani F, Mahdavi M, Bahadorikhalili S. Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water. Research on Chemical Intermediates. 2021;47(10):4101-4112.
BibTex	@article{ author = {Sayahi MH and Shamkhani F and Mahdavi M and Bahadorikhalili S}, title = {Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water}, journal = {Research on Chemical Intermediates}, volume = {47}, number = {10}, pages = {4101-4112}, year = {2021} }
RIS	TY - JOUR AU - Sayahi MH AU - Shamkhani F AU - Mahdavi M AU - Bahadorikhalili S TI - Efficient Synthesis of Chromeno[4,3-B]Pyrano[3,4-E]Pyridine-6,8-Dione Derivatives Via Multicomponent One-Pot Reaction Under Mild Reaction Conditions in Water JO - Research on Chemical Intermediates VL - 47 IS - 10 SP - 4101 EP - 4112 PY - 2021 ER -

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