In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex

In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex Publisher Pubmed

Vaezi A^{1, 2} ; Fakhim H^{3, 4} ; Arastehfar A⁵ ; Shokohi T¹ ; Hedayati MT¹ ; Khodavaisy S⁶ ; Rezaeimatehkolaei A⁷ ; Badiee P⁸ ; Hagen F⁹ ; Lassflorl C¹⁰ ; Dannaoui E¹¹ ; Meis JF^{9, 12} ; Badali H¹

Show Affiliations

1. Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2. Student Research Committee Center, Mazandaran University of Medical Sciences, Sari, Iran
3. Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
5. Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands
6. Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
7. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
8. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
9. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands
10. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
11. Faculte de Medecine, APHP, Universite Paris-Descartes, Hopital Europeen Georges Pompidou, Unite de Parasitologie-Mycologie, Paris, France
12. Center of Expertise in Mycology Radboudumc, CWZ, Nijmegen, Netherlands

Source: Mycoses Published:2018

Abstract

Aspergillus terreus infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other Aspergillus species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n = 36) and environmental (n = 45) A. terreus isolates. In vitro antifungal susceptibility was performed using the CLSI M38-A2 procedure. Amphotericin B exhibited the highest MICs (MIC range, 0.125-4 μg/mL; MIC90, 2 μg/mL), followed by terbinafine (MIC range, 0.002-1 μg/mL; MIC90, 1 μg/mL). Only one isolate (1/81) showed amphotericin B MIC above the epidemiologic cut-off value (ECV; 4 μg/mL). None of the isolates had a MIC of ≥ ECV for voriconazole, itraconazole and posaconazole. The reasons for the difference in amphotericin B susceptibility patterns between studies remain unknown. The genetic and species diversity, clinical, environmental and ecological factors in Terrei section on various amphotericin B susceptibility profiles in different countries should be considered more as the main reasons associated with these differences. © 2017 Blackwell Verlag GmbH

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Style	Citing Format
MLA	Vaezi A, et al.. "In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex." Mycoses, vol. 61, no. 2, 2018, pp. 134-142.
APA	Vaezi A, Fakhim H, Arastehfar A, Shokohi T, Hedayati MT, Khodavaisy S, Rezaeimatehkolaei A, Badiee P, Hagen F, Lassflorl C, Dannaoui E, Meis JF, Badali H (2018). In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex. Mycoses, 61(2), 134-142.
Chicago	Vaezi A, Fakhim H, Arastehfar A, Shokohi T, Hedayati MT, Khodavaisy S, Rezaeimatehkolaei A, et al.. "In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex." Mycoses 61, no. 2 (2018): 134-142.
Harvard	Vaezi A et al. (2018) 'In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex', Mycoses, 61(2), pp. 134-142.
Vancouver	Vaezi A, Fakhim H, Arastehfar A, Shokohi T, Hedayati MT, Khodavaisy S, et al.. In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex. Mycoses. 2018;61(2):134-142.
BibTex	@article{ author = {Vaezi A and Fakhim H and Arastehfar A and Shokohi T and Hedayati MT and Khodavaisy S and Rezaeimatehkolaei A and Badiee P and Hagen F and Lassflorl C and Dannaoui E and Meis JF and Badali H}, title = {In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex}, journal = {Mycoses}, volume = {61}, number = {2}, pages = {134-142}, year = {2018} }
RIS	TY - JOUR AU - Vaezi A AU - Fakhim H AU - Arastehfar A AU - Shokohi T AU - Hedayati MT AU - Khodavaisy S AU - Rezaeimatehkolaei A AU - Badiee P AU - Hagen F AU - Lassflorl C AU - Dannaoui E AU - Meis JF AU - Badali H TI - In Vitro Antifungal Activity of Amphotericin B and 11 Comparators Against Aspergillus Terreus Species Complex JO - Mycoses VL - 61 IS - 2 SP - 134 EP - 142 PY - 2018 ER -

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