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Evaluation of Bioactivity and Biocompatibility of Silk Fibroin/Tio2 Nanocomposite Publisher



Johari N1 ; Madaah Hosseini HR1 ; Taromi N2, 3, 4 ; Arasteh S5 ; Kazemnejad S5 ; Samadikuchaksaraei A2, 3, 4
Authors
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Authors Affiliations
  1. 1. Department of Materials Science and Engineering, Sharif University of Technology, Tehran, 1458889694, Iran
  2. 2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  3. 3. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  4. 4. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  5. 5. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, 19615, Iran

Source: Journal of Medical and Biological Engineering Published:2018


Abstract

Biodegradable polymer/bioceramic nanocomposites are osteoconductive and can accelerate healing of bone tissue. In this research, silk fibroin (SF)/titanium dioxide (TiO2) nanocomposites were synthesized using different concentrations of TiO2 nanoparticles (0, 5, 10, 15 and 20 wt%). The SF/TiO2 nanocomposites were studied in terms of bioactivity and biocompatibility. The in vitro assessment of osteoblasts compatibility indicated that SF inclusion rendered nanocomposite biocompatible whereas presence of TiO2 nanoparticles allowed the cells to adhere and grow on nanocomposite surface and enhanced the bioactivity of the composite. © 2017, Taiwanese Society of Biomedical Engineering.