Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells

Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells Publisher Pubmed

Shahhosseini R¹ ; Pakmehr S^{2, 3} ; Elhami A² ; Shakir MN⁴ ; Alzahrani AA⁵ ; Alhamdani MM⁶ ; Abosoda M^{7, 8, 9} ; Alsalamy A¹⁰ ; Mohammadidehcheshmeh M¹¹ ; Maleki TE¹² ; Saffarfar H¹³ ; Alikhiavi P¹⁴

Show Affiliations

1. Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkiye
2. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3. Ahvaz Jundishapur University of Medical Sciences Ahvaz, Ahvaz, Iran
4. Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
5. Department of Surgery, College of Medicine, Taif University, Taif, Saudi Arabia
6. Pharmaceutics Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq
7. College of Pharmacy, The Islamic University, Najaf, Iraq
8. College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq
9. College of Pharmacy, The Islamic University of Babylon, Babylon, Iraq
10. College of Pharmacy, Imam Ja’afar Al‐Sadiq University, Al‐Muthanna, Al-Samawa, 66002, Iraq
11. Department of Biology, Sciences and Arts University, Yazd, Iran
12. Shahid Beheshti University of Medical Sciences, Tehran, Iran
13. Cardiovascular Research Center, Tehran University of Medical Sciences, Tehran, Iran
14. Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Clinical and Experimental Medicine Published:2025

Abstract

Metastatic disease and cancer recurrence are the primary causes of cancer-related deaths. Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are the driving forces behind the spread of cancer cells. The emergence and development of liquid biopsy using rare CTCs as a minimally invasive strategy for early-stage tumor detection and improved tumor management is a promising advancement in recent years. However, before blood sample analysis and clinical translation, precise isolation of CTCs from patients’ blood based on their biophysical properties, followed by molecular identification of CTCs using single-cell multi-omics technologies is necessary to understand tumor heterogeneity and provide effective diagnosis and monitoring of cancer progression. Additionally, understanding the origin, morphological variation, and interaction between CTCs and the primary and metastatic tumor niche, as well as and regulatory immune cells, will offer new insights into the development of CTC-based advanced tumor targeting in the future clinical trials. Graphical Abstract: (Figure presented.) © The Author(s) 2024.

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Style	Citing Format
MLA	Shahhosseini R, et al.. "Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells." Clinical and Experimental Medicine, vol. 25, no. 1, 2025, pp. -.
APA	Shahhosseini R, Pakmehr S, Elhami A, Shakir MN, Alzahrani AA, Alhamdani MM, Abosoda M, Alsalamy A, Mohammadidehcheshmeh M, Maleki TE, Saffarfar H, Alikhiavi P (2025). Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells. Clinical and Experimental Medicine, 25(1), -.
Chicago	Shahhosseini R, Pakmehr S, Elhami A, Shakir MN, Alzahrani AA, Alhamdani MM, Abosoda M, et al.. "Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells." Clinical and Experimental Medicine 25, no. 1 (2025): -.
Harvard	Shahhosseini R et al. (2025) 'Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells', Clinical and Experimental Medicine, 25(1), pp. -.
Vancouver	Shahhosseini R, Pakmehr S, Elhami A, Shakir MN, Alzahrani AA, Alhamdani MM, et al.. Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells. Clinical and Experimental Medicine. 2025;25(1):-.
BibTex	@article{ author = {Shahhosseini R and Pakmehr S and Elhami A and Shakir MN and Alzahrani AA and Alhamdani MM and Abosoda M and Alsalamy A and Mohammadidehcheshmeh M and Maleki TE and Saffarfar H and Alikhiavi P}, title = {Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells}, journal = {Clinical and Experimental Medicine}, volume = {25}, number = {1}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Shahhosseini R AU - Pakmehr S AU - Elhami A AU - Shakir MN AU - Alzahrani AA AU - Alhamdani MM AU - Abosoda M AU - Alsalamy A AU - Mohammadidehcheshmeh M AU - Maleki TE AU - Saffarfar H AU - Alikhiavi P TI - Current Biological Implications and Clinical Relevance of Metastatic Circulating Tumor Cells JO - Clinical and Experimental Medicine VL - 25 IS - 1 SP - EP - PY - 2025 ER -

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