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Contradictory Effects of 6-Shogaol on the Human Cervical Cancer Cell Line Hela Through Network Analysis Publisher



Arjmand B1 ; Azodi MZ2 ; Tavirani MR3 ; Esmaeili S4 ; Vafaee R5, 6
Authors
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Authors Affiliations
  1. 1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Surgery Department, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Critical Care Quality Improvement Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Research Journal of Pharmacognosy Published:2022


Abstract

Background and objectives: To identify new targets for cancer clinical management, protein-protein interaction (PPI) network analysis of proteome data could accelerate this approach. For this aim, proteins with differential expressions in 6-shogaol exposure from proteomics study underwent protein-protein interaction (PPI) network analysis. Methods: Cytoscape version 3.8.2 and its plug-ins including NetworkAnalyzer and ClueGO2.5.8+CluePedia1.5.8 were applied for the construction and the corresponding analysis of the network. Results: A number of six differentially expressed proteins (DEPs) were identified as hub-bottlenecks of the PPI network. The critical proteins GAPDH, ENO1, HSP90AB1, ACTG1, RPSA, and CALR were determined as central elements of the analyzed network and their related biological processes were identified as “protein folding chaperones” and “glucose catabolic process”. Conclusion: Potential candidates may be predicted as both anticancer agents and promoters of side effects of 6-shogaol in cancer treatment; however, complementary studies are required to provide validation and deeper understating of its molecular behavior in this regard. © 2022. Open access.
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