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Association Between Nicotinamide Phosphoribosyltransferase and De Novo Lipogenesis in Nonalcoholic Fatty Liver Disease Publisher Pubmed



Amirkalali B1 ; Sohrabi MR1 ; Esrafily A2 ; Jalali M3 ; Gholami A4, 5 ; Hosseinzadeh P1 ; Keyvani H6 ; Shidfar F7 ; Zamani F1
Authors
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Authors Affiliations
  1. 1. Gastrointestinal and Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Firoozgar Hospital, Karim khan Boulevard Behafarin Street, Tehran, 1593748711, Iran
  2. 2. Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Nutrition and Biochemistry, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Public Health, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran
  5. 5. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Source: Medical Principles and Practice Published:2017


Abstract

Objective: This study explored the association between serum nicotinamide phosphoribosyltransferase (NAMPT) and hepatic de novo lipogenesis (DNL) in nonalcoholic fatty liver disease (NAFLD) and determined whether or not this association is sex dependent. Subjects and Methods: In this cross-sectional study, 62 consecutive patients (32 males, 30 females) with NAFLD were recruited. Serum NAMPT (by ELISA), palmitic acid, and the DNL index of erythrocyte membranes as markers of hepatic DNL (by gas chromatography) were analyzed. The controlled attenuation parameter (CAP) and body impedance analyzer were used to assess hepatic and body fat, respectively. Univariate and multiple linear regressions (to adjust for confounders) were used to analyze the association of serum NAMPT with palmitic acid, DNL index, CAP, and body fat. Results: The respective values of serum NAMPT (2.44 ± 1.03 vs. 2.45 ± 1.13 ng/mL, p = 0.98), DNL index (3.11 [2.60-3.71] vs. 3.05 [2.40-3.59], p = 0.90), and palmitic acid (20.55% [15.34-24.04] vs. 22.64% [21.15-25.95], p = 0.07) were not significantly different between men and women, but those of CAP (326 [300-340] vs. 300 [261.25-329], p = 0.002) and body fat (37.71 ± 3.80 vs. 26.60 ± 5.70, p < 0.001) were significantly higher in women. In women, serum NAMPT had a significant negative association with the DNL index (β = -0.56, p = 0.01). The DNL index also had a significant negative association with body fat (β = -0.46, p = 0.02). In men, the only significant association was the positive association between serum NAMPT and CAP (β = 0.35, p = 0.035). Conclusion: Higher serum NAMPT in women was associated with a lower hepatic DNL index, while in men it was associated with higher hepatic fat and had no association with the DNL index. Therefore, the serum NAMPT level interpretation for NAFLD prognosis is probably sex dependent. © 2017 S. Karger AG, Basel.
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