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Nanoformulated Herbal Bioactives for the Treatment of Neurodegenerative Disorders Publisher



Sajadimajd S1 ; Moradi SZ2, 3 ; Akbari V1, 4 ; Aghaz F5 ; Farzaei MH6, 7
Authors
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Authors Affiliations
  1. 1. Department of Biology, Razi University, Kermanshah, Iran
  2. 2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Research Center of Oils and Fats, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Kermanshah University of Medical Science, Kermanshah, Iran
  7. 7. Department of Traditional Pharmacy, Tehran University of Medical Science, Tehran, Iran

Source: Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities Published:2022


Abstract

Neurodegenerative diseases (NDs) refer to a number of chronic progressive neurological disorders due to degradation and dysfunction of neurons. A great promise for the prevention of many NDs, herbal bioactives offer better opportunities than synthetic medical agents. However, given the low solubility and bioavailability, nanoformulation enables controlled release and therapeutic effects of natural products. In this line, the objective of this study is to evaluate the therapeutic effects of natural products and their nanostructures in several types of neurodegenerative in vitro and in vivo models. The neuroprotective potential of a number of plants and their constituents from Ayurveda, Iranian, South American, African, and Chinese medicine has been reported in NDs. Owing to the low blood-brain penetration of natural products, the effectiveness of nanoformulated forms was evaluated in NDs. The cumulative of these observations reveals that nanotechnology-based natural products hold great promise for management and treatment of NDs. © 2022 Elsevier Inc. All rights reserved.
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