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Differential Antibody Response to Sars-Cov-2 Antigens in Recovered and Deceased Iranian Covid-19 Patients Publisher Pubmed



Maghsood F1 ; Hassani D1 ; Salimi V2 ; Kardar GA3 ; Khoshnoodi J1 ; Ghaderi A4 ; Raeeskarami SR5 ; Rostamian A6 ; Seyyedsalehi MS7 ; Ahmadi Fesharaki R1 ; Jedditehrani M8 ; Zarnani AH1 ; Amiri MM1 ; Shokri F1
Authors
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Authors Affiliations
  1. 1. Department of Immunology and School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Immunology Asthma and Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cancer Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Pediatrics, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Monoclonal Antibody Research Center, Avicenna Research Institute, Acecr, Tehran, Iran

Source: Viral Immunology Published:2021


Abstract

The coronavirus infectious disease 2019 (COVID-19), which is initiated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed critical challenges to global health. Understanding the kinetic of SARS-CoV-2-specific IgM and IgG responses in different subsets of COVID-19 patients is crucial to get insight into the humoral immune response elicited against the virus. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and receptor-binding domain (RBD) of spike protein in two groups of recovered and deceased COVID-19 patients. The levels of IgM and IgG specific to N and RBD proteins were detected by ELISA. N-and RBD-specific IgM was higher in deceased patients in comparison with recovered patients, while there was no significant difference in N-and RBD-specific IgG between the two groups. A significant correlation was observed between IgG and IgM titers against RBD and N, in both groups of patients. These results argue against impaired antibody response in deceased COVID-19 patients. © 2021 Mary Ann Liebert, Inc., publishers.
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