Differential Antibody Response to Sars-Cov-2 Antigens in Recovered and Deceased Iranian Covid-19 Patients Publisher Pubmed



Maghsood F¹ ; Hassani D¹ ; Salimi V² ; Kardar GA³ ; Khoshnoodi J¹ ; Ghaderi A⁴ ; Raeeskarami SR⁵ ; Rostamian A⁶ ; Seyyedsalehi MS⁷ ; Ahmadi Fesharaki R¹ ; Jedditehrani M⁸ ; Zarnani AH¹ ; Amiri MM¹ ; Shokri F¹
Source: Viral Immunology Published:2021

Abstract

The coronavirus infectious disease 2019 (COVID-19), which is initiated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed critical challenges to global health. Understanding the kinetic of SARS-CoV-2-specific IgM and IgG responses in different subsets of COVID-19 patients is crucial to get insight into the humoral immune response elicited against the virus. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and receptor-binding domain (RBD) of spike protein in two groups of recovered and deceased COVID-19 patients. The levels of IgM and IgG specific to N and RBD proteins were detected by ELISA. N-and RBD-specific IgM was higher in deceased patients in comparison with recovered patients, while there was no significant difference in N-and RBD-specific IgG between the two groups. A significant correlation was observed between IgG and IgM titers against RBD and N, in both groups of patients. These results argue against impaired antibody response in deceased COVID-19 patients. © 2021 Mary Ann Liebert, Inc., publishers.