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Epigenetic Modifications and Epigenetic Based Medication Implementations of Autoimmune Diseases Publisher Pubmed



Ahmadi M1, 2, 3 ; Gharibi T1, 2 ; Dolati S1, 2 ; Rostamzadeh D1, 2 ; Aslani S4 ; Baradaran B2, 3 ; Younesi V5 ; Yousefi M1, 2, 3
Authors
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Authors Affiliations
  1. 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pishtaz Teb Zaman Diagnostics, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2017


Abstract

Recent genome-wide association studies have documented a number of genetic variants to explain mechanisms underlying autoimmune diseases. However, the precise etiology of autoimmune diseases remains largely unknown. Epigenetic mechanisms like alterations in the post-translational modification of histones and DNA methylation may potentially cause a breakdown of immune tolerance and the perpetuation of autoreactive responses. Recently, several studies both in experimental models and clinical settings proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically, data support the impact of epigenetic changes in autoimmune diseases, in some cases based on mechanistical observations. Epigenetic therapy already being employed in hematopoietic malignancies may also be associated with beneficial effects in autoimmune diseases. In this review, we will discuss on what we know and expect about the treatment of autoimmune disease based on epigenetic aberrations. © 2016 Elsevier Masson SAS
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