Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Role of Mir153 and Mir455-5P Expression in Oral Squamous Cell Carcinoma Isolated From Plasma Publisher Pubmed



Baber S1 ; Bayat M1, 2 ; Mohamadnia A3, 4 ; Shamshiri A5 ; Shakib PA6 ; Bahrami N2, 7
Authors

Source: Asian Pacific Journal of Cancer Prevention Published:2021


Abstract

Background: Despite the notable advances in modern surgery and radiotherapy,no significant increase in the five year survival rate of oral squamous cell carcinoma has been reported. Collecting evidence demonstrates that miR 153 and miR 455-5p play a key role in growth and progression of oral cancer. Early detection of OSCC is important for enhancing patient quality of life and clinical treatment.For this reason, biomarkers or tumour markers offer an opportunity to intervene and avoid development of oral cancer. Methods: A total of 50 blood samples from patients from both genders (25 OSCC and 25 healthy people/control groups) were obtained to determine the expression of miR153 and miR455-5p using Real time Polymerase chain reaction and t test. Results: In general by using the formula ? ct, it is evident that the miR 153 expression in peripheral blood is lower in patients than in healthy individuals (1.97) while the miR 455-5p expression in peripheral blood is higher in patients than in healthy individuals (2.56). Conclusion: We conclude that miR153 and miR 455-5p expression in serum can function as a diagnostic screening test for the early detection of oral squamous cell carcinoma. © 2021. All rights reserved.
Other Related Docs
15. Ectopic Expression of Mirna-21 and Mirna-205 in Non-Small Cell Lung Cancer, International Journal of Cancer Management (2019)
19. Reproducible and Reliable Real-Time Pcr Assay to Measure Mature Form of Mir-141, Applied Immunohistochemistry and Molecular Morphology (2016)
20. Oral Tumors in Children: Diagnosis and Management, Journal of Cellular Biochemistry (2018)