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Asymmetric Dimethylarginine and Soluble Inter-Cellular Adhesion Molecule-1 Serum Levels Alteration Following Ginger Supplementation in Patients With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Zarezadeh M1 ; Saedisomeolia A1 ; Khorshidi M4 ; Kord Varkane H5 ; Makhdoomi Arzati M1 ; Abdollahi M6 ; Yekaninejad MS3 ; Hashemi R2 ; Effatpanah M7 ; Mohammadzadeh Honarvar N1
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Geriatric Medicine, Ziaeian Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biostatistics and Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Iran
  4. 4. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. AmirAlam Hospital Complex, Marvasti Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Complementary and Integrative Medicine Published:2019


Abstract

Patients with type 2 diabetes mellitus (T2DM) are prone to cardiovascular disease (CVD) due to inflammation process and oxidative stress. ADMA (Asymmetric dimethylarginine) and ICAM-1 (inter-cellular adhesion molecule-1) play an important role in CVD pathogenesis. Ginger as an anti-oxidant and anti-inflammation can effect on these biomarkers. The aim of present study was to characterize the effect of ginger supplementation on ADMA and ICAM-1 serum levels in patients with T2DM. The present study is a randomized double-blind clinical trial which is conducted among 45 diabetic patients (nginger=23, nplacebo=22). The participants were randomly divided into two intervention and placebo groups which were received 2?g ginger powder and 2g wheat flour for 10weeks, respectively. ADMA and ICAM-1 concentration were measured by ELISA method. Ginger supplementation decreased ADMA serum levels significantly (P=0.002) and sICAM-1 serum levels marginally (P=0.097) in supplementation group after intervention. No significant difference was observed between placebo and supplementation groups. Present study was conducted among patients with type 2 diabetes mellitus to investigate the effect of ginger supplementation on ADMA and sICAM-1 levels. There was a significant decrement in ADMA serum concentration and slight reduction in sICAM-1 levels in intervention group. The amount of reduction in both biomarkers was not statistically significant in between-groups comparison. © 2019 Walter de Gruyter GmbH, Berlin/Boston.
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