Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synthesis, Characterization, and in Vitro Biological Evaluation of Copper-Containing Magnetic Bioactive Glasses for Hyperthermia in Bone Defect Treatment Publisher Pubmed



Koohkan R1 ; Hooshmand T1 ; Mohebbikalhori D2 ; Tahriri M3 ; Marefati MT4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Dental Biomaterials, School of Dentistry, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, North-Kargar Street, Tehran, 14146, Iran
  2. 2. Chemical Engineering Department, Faculty of Engineering, University of Sistan and Baluchestan, Daneshgah Street, Zahedan, Iran
  3. 3. School of Dentistry, Marquette University, Milwaukee, 53233, WI, United States
  4. 4. School of Metallurgy and Materials Engineering, University of Tehran, North-Kargar Street, Tehran, 14395, Iran

Source: ACS Biomaterials Science and Engineering Published:2018


Abstract

Hyperthermia treatment induced by magnetic mesoporous glasses has been applied as a potential therapeutic approach for bone defects due to malignant tumors. The objective of this study was to synthesize and characterize the structural and biological properties of magnetic bioactive glasses (BGs) for producing multifunctional materials. The effect of the addition of copper (Cu) to the bioactive glass composition was also evaluated. Fe BG and FeCu BG as magnetic mesoporous BGs, and Cu BG as mesoporous BG were synthesized and dried by template sol-gel method. Then the synthesized bioglasses were characterized and analyzed using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive electron disperse spectroscopy (EDS), Brunauer-Emmett-Teller (BET), and vibrating sample magnetometer (VSM). In addition, the antibacterial behavior, cytotoxicity assay (MTT test), proliferation assay of HUVEC cell assay, and bioactivity (ALP activity test) of the synthesized BGs were evaluated. The characterization results exhibited that the synthesized powders formed mesoporous glasses with nanoparticle morphology, good surface area, and magnetic properties. The synthesized BGs also demonstrated suitable biological behavior. The magnetic saturation of bioactive glasses was increased by the addition of copper oxide. A two-phase structure was observed for the magnetic glasses compared to the copper-containing glasses, thus making them suitable for drug delivery systems. The antibacterial behavior was found to be better for the Cu BG and Fe BG compared to the FeCu BG. However, the least amount of cytotoxicity was observed for the Fe BG and FeCu BG, compared to the Cu BG. In addition, the Fe-containing BGs compared with the control group showed a lack of HUVEC cell proliferation and angiogenesis motivation. From the ALP assay, higher bioactivity for the magnetic bioglasses in the presence of mesenchymal cells was found. From the results of this in vitro study, the Cu-containing magnetic bioglass (FeCu BG) could be considered as a new generation of magnetic glasses for inducing hyperthermia in treatment of bone defects due to malignant tumors. However, further in vitro and in vivo studies are required to confirm their applications in healing of bone defects and tissue engineering. © 2018 American Chemical Society.
Related Docs
View other Related Docs
1. Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses, Ceramics International (2018)
2. Mesoporous Bioactive Glasses: Promising Platforms for Antibacterial Strategies, Acta Biomaterialia (2018)
3. Mesoporous Bioactive Glasses (Mbgs) in Cancer Therapy: Full of Hope and Promise, Materials Letters (2019)
4. Comparative Evaluation of Magnetic Hyperthermia Performance and Biocompatibility of Magnetite and Novel Fe-Doped Hardystonite Nanoparticles for Potential Bone Cancer Therapy, Materials Science and Engineering C (2019)
5. Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering, Trends in Biotechnology (2018)
6. Iron (Fe)-Doped Mesoporous 45S5 Bioactive Glasses: Implications for Cancer Therapy, Translational Oncology (2022)
7. Bioactive Glasses and Calcium Phosphates, Biomaterials for Oral and Dental Tissue Engineering (2017)
8. Synthesis and Characterization of Novel Mesoporous Strontium-Modified Bioactive Glass Nanospheres for Bone Tissue Engineering Applications, Microporous and Mesoporous Materials (2020)
Experts (# of related papers)
View all Related Experts
Nasrin Lotfibakhshaiesh (3)
Mahmoud Azami (2)
Other Related Docs
9. Synthesis and Physico-Chemical Characterization of Fluoride (F)- a Nd Silver (Ag)-Substituted Sol-Gel Mesoporous Bioactive Glasses, Biomedical Glasses (2019)
10. Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass, Silicon (2017)
11. Synergistic Combination of Bioactive Glasses and Polymers for Enhanced Bone Tissue Regeneration, Materials Today: Proceedings (2018)
12. Synthesis and Optical Properties of Cysteamine-Capped Zns Quantum Dots for Aflatoxin Quantification, Journal of Alloys and Compounds (2017)
13. Poly(Lactic-Co-Glycolic Acid)(Plga)/Tio2 Nanotube Bioactive Composite As a Novel Scaffold for Bone Tissue Engineering: In Vitro and in Vivo Studies, Biologicals (2018)
14. Evaluation of the in Vitro Biodegradation and Biological Behavior of Poly(Lactic-Co-Glycolic Acid)/Nano-Fluorhydroxyapatite Composite Microsphere-Sintered Scaffold for Bone Tissue Engineering, Journal of Bioactive and Compatible Polymers (2018)
15. Preparation of a Biomimetic Composite Scaffold From Gelatin/Collagen and Bioactive Glass Fibers for Bone Tissue Engineering, Materials Science and Engineering C (2016)
16. Functionalization and Surface Modifications of Bioactive Glasses (Bgs): Tailoring of the Biological Response Working on the Outermost Surface Layer, Materials (2019)
17. Bioactive Glasses Entering the Mainstream, Drug Discovery Today (2018)
18. Synthesis, Physico-Chemical and Biological Characterization of Strontium and Cobalt Substituted Bioactive Glasses for Bone Tissue Engineering, Journal of Non-Crystalline Solids (2016)
19. Selective Contribution of Bioactive Glasses to Molecular and Cellular Pathways, ACS Biomaterials Science and Engineering (2020)
20. Preparation of a Plga-Coated Porous Bioactive Glass Scaffold With Improved Mechanical Properties for Bone Tissue Engineering Approaches, Regenerative Engineering and Translational Medicine (2021)
21. Strontium- and Cobalt-Substituted Bioactive Glasses Seeded With Human Umbilical Cord Perivascular Cells to Promote Bone Regeneration Via Enhanced Osteogenic and Angiogenic Activities, Acta Biomaterialia (2017)
22. Exploring the Various Effects of Cu Doping in Hydroxyapatite Nanoparticle, Scientific Reports (2024)
23. Optimisation and Biological Activities of Bioceramic Robocast Scaffolds Provided With an Oxygen-Releasing Coating for Bone Tissue Engineering Applications, Ceramics International (2019)
24. Nanomaterials-Based Electrochemical Immunosensors for Cardiac Troponin Recognition: An Illustrated Review, TrAC - Trends in Analytical Chemistry (2016)