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Synthesis and Evaluation of Antiviral Activities of Novel Sonochemical Silver Nanorods Against Hiv and Hsv Viruses Publisher



Etemadzade M1 ; Ghamarypour A2 ; Zabihollahi R6 ; Shabbak G1 ; Shirazi M2 ; Sahebjamee H3 ; Vaziri AZ4 ; Assadi A4 ; Ardestani MS4 ; Shandiz SAS5 ; Aghasadeghi MR6
Authors
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Authors Affiliations
  1. 1. Department of Biology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Biochemistry and Biophysics, School of Biological Sciences, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
  4. 4. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Young Researchers and Elite Club, East Tehran Branch, Islamic Azad University, Tehran, Iran
  6. 6. Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran

Source: Asian Pacific Journal of Tropical Disease Published:2016


Abstract

Objective To evaluate the effect of novel sonochemical silver nanorods on HIV and herpes simplex virus type 1 (HSV-1) viruses in human cervical cancer HeLa cells. Methods The formation of silver nanorods conjugated with sodium 2-mercaptoethane sulfonate (Ag-MES) was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analysis. The antiviral activity of this Ag-MES was examined against HIV and HSV-1 virus replication. Results The characterizations of Ag-MES and physiochemical structure were determined by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analysis. Approximately entire viral replication was inhibited by Ag-MES at 10 μmol/mL concentration. About 90% of HSV virions failed to replicate in the present of this concentration of nanorods. However, HIV showed more sensitivity to Ag-MES than HSV-1. Conclusions According to the obtained data, the synthesized sonochemical silver nanorod in this study is a promising candidate for further drug discovery investigation. © 2016 Asian Pacific Tropical Medicine Press