Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence

Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence Publisher Pubmed

Moody S¹ ; Senkin S² ; Islam SMA^{3, 4, 5} ; Wang J¹ ; Nasrollahzadeh D^{2, 6} ; Cortez Cardoso Penha R² ; Fitzgerald S¹ ; Bergstrom EN^{3, 4, 5} ; Atkins J² ; He Y^{3, 4, 5} ; Khandekar A^{3, 4, 5} ; Smithbyrne K² ; Carreira C⁷ ; Gaborieau V² Show All Authors

Moody S¹
Senkin S²
Islam SMA^{3, 4, 5}
Wang J¹
Nasrollahzadeh D^{2, 6}
Cortez Cardoso Penha R²
Fitzgerald S¹
Bergstrom EN^{3, 4, 5}
Atkins J²
He Y^{3, 4, 5}
Khandekar A^{3, 4, 5}
Smithbyrne K²
Carreira C⁷
Gaborieau V²
Latimer C¹
Thomas E¹
Abnizova I¹
Bucciarelli PE¹
Jones D¹
Teague JW¹
Abediardekani B²
Serra S⁸
Scoazec JY⁹
Saffar H¹⁰
Azmoudehardalan F¹¹
Sotoudeh M⁶
Nikmanesh A⁶
Poustchi H⁶
Niavarani A⁶
Gharavi S⁶
Eden M¹²
Richman P¹³
Campos LS¹⁴
Fitzgerald RC¹⁵
Ribeiro LF¹⁶
Soareslima SC¹⁶
Dzamalala C¹⁷
Mmbaga BT¹⁸
Shibata T¹⁹
Menya D²⁰
Goldstein AM²¹
Hu N²¹
Malekzadeh R⁶
Fazel A²²
Mccormack V²³
Mckay J²
Perdomo S²
Scelo G^{2, 24}
Chanudet E²
Humphreys L¹
Alexandrov LB^{3, 4, 5}
Brennan P²
Stratton MR¹

Source: Nature Genetics Published:2021

Abstract

Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here we combine the fields of mutational signature analysis with cancer epidemiology to study 552 ESCC genomes from eight countries with varying incidence rates. Mutational profiles were similar across all countries studied. Associations between specific mutational signatures and ESCC risk factors were identified for tobacco, alcohol, opium and germline variants, with modest impacts on mutation burden. We find no evidence of a mutational signature indicative of an exogenous exposure capable of explaining differences in ESCC incidence. Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC)-associated mutational signatures single-base substitution (SBS)2 and SBS13 were present in 88% and 91% of cases, respectively, and accounted for 25% of the mutation burden on average, indicating that APOBEC activation is a crucial step in ESCC tumor development. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

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Style	Citing Format
MLA	Moody S, et al.. "Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence." Nature Genetics, vol. 53, no. 11, 2021, pp. 1553-1563.
APA	Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, Bergstrom EN, Atkins J, He Y, Khandekar A, Smithbyrne K, Carreira C, Gaborieau V, Latimer C, Thomas E, Abnizova I, Bucciarelli PE, Jones D, ... Stratton MR (2021). Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence. Nature Genetics, 53(11), 1553-1563.
Chicago	Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, et al.. "Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence." Nature Genetics 53, no. 11 (2021): 1553-1563.
Harvard	Moody S et al. (2021) 'Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence', Nature Genetics, 53(11), pp. 1553-1563.
Vancouver	Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, et al.. Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence. Nature Genetics. 2021;53(11):1553-1563.
BibTex	@article{ author = {Moody S and Senkin S and Islam SMA and Wang J and Nasrollahzadeh D and Cortez Cardoso Penha R and Fitzgerald S and Bergstrom EN and Atkins J and He Y and Khandekar A and Smithbyrne K and Carreira C and Gaborieau V and Latimer C and Thomas E and Abnizova I and Bucciarelli PE and Jones D and Teague JW and Abediardekani B and Serra S and Scoazec JY and Saffar H and Azmoudehardalan F and Sotoudeh M and Nikmanesh A and Poustchi H and Niavarani A and Gharavi S and Eden M and Richman P and Campos LS and Fitzgerald RC and Ribeiro LF and Soareslima SC and Dzamalala C and Mmbaga BT and Shibata T and Menya D and Goldstein AM and Hu N and Malekzadeh R and Fazel A and Mccormack V and Mckay J and Perdomo S and Scelo G and Chanudet E and Humphreys L and Alexandrov LB and Brennan P and Stratton MR}, title = {Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence}, journal = {Nature Genetics}, volume = {53}, number = {11}, pages = {1553-1563}, year = {2021} }
RIS	TY - JOUR AU - Moody S AU - Senkin S AU - Islam SMA AU - Wang J AU - Nasrollahzadeh D AU - Cortez Cardoso Penha R AU - Fitzgerald S AU - Bergstrom EN AU - Atkins J AU - He Y AU - Khandekar A AU - Smithbyrne K AU - Carreira C AU - Gaborieau V AU - Latimer C AU - Thomas E AU - Abnizova I AU - Bucciarelli PE AU - Jones D AU - Teague JW AU - Abediardekani B AU - Serra S AU - Scoazec JY AU - Saffar H AU - Azmoudehardalan F AU - Sotoudeh M AU - Nikmanesh A AU - Poustchi H AU - Niavarani A AU - Gharavi S AU - Eden M AU - Richman P AU - Campos LS AU - Fitzgerald RC AU - Ribeiro LF AU - Soareslima SC AU - Dzamalala C AU - Mmbaga BT AU - Shibata T AU - Menya D AU - Goldstein AM AU - Hu N AU - Malekzadeh R AU - Fazel A AU - Mccormack V AU - Mckay J AU - Perdomo S AU - Scelo G AU - Chanudet E AU - Humphreys L AU - Alexandrov LB AU - Brennan P AU - Stratton MR TI - Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence JO - Nature Genetics VL - 53 IS - 11 SP - 1553 EP - 1563 PY - 2021 ER -

Style

Citing Format

MLA

Moody S, et al.. "Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence." Nature Genetics, vol. 53, no. 11, 2021, pp. 1553-1563.

APA

Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, Bergstrom EN, Atkins J, He Y, Khandekar A, Smithbyrne K, Carreira C, Gaborieau V, Latimer C, Thomas E, Abnizova I, Bucciarelli PE, Jones D, ... Stratton MR (2021). Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence. Nature Genetics, 53(11), 1553-1563.

Chicago

Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, et al.. "Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence." Nature Genetics 53, no. 11 (2021): 1553-1563.

Harvard

Moody S et al. (2021) 'Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence', Nature Genetics, 53(11), pp. 1553-1563.

Vancouver

Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, et al.. Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence. Nature Genetics. 2021;53(11):1553-1563.

BibTex

@article{ author = {Moody S and Senkin S and Islam SMA and Wang J and Nasrollahzadeh D and Cortez Cardoso Penha R and Fitzgerald S and Bergstrom EN and Atkins J and He Y and Khandekar A and Smithbyrne K and Carreira C and Gaborieau V and Latimer C and Thomas E and Abnizova I and Bucciarelli PE and Jones D and Teague JW and Abediardekani B and Serra S and Scoazec JY and Saffar H and Azmoudehardalan F and Sotoudeh M and Nikmanesh A and Poustchi H and Niavarani A and Gharavi S and Eden M and Richman P and Campos LS and Fitzgerald RC and Ribeiro LF and Soareslima SC and Dzamalala C and Mmbaga BT and Shibata T and Menya D and Goldstein AM and Hu N and Malekzadeh R and Fazel A and Mccormack V and Mckay J and Perdomo S and Scelo G and Chanudet E and Humphreys L and Alexandrov LB and Brennan P and Stratton MR}, title = {Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence}, journal = {Nature Genetics}, volume = {53}, number = {11}, pages = {1553-1563}, year = {2021} }

RIS

TY - JOUR
AU - Moody S
AU - Senkin S
AU - Islam SMA
AU - Wang J
AU - Nasrollahzadeh D
AU - Cortez Cardoso Penha R
AU - Fitzgerald S
AU - Bergstrom EN
AU - Atkins J
AU - He Y
AU - Khandekar A
AU - Smithbyrne K
AU - Carreira C
AU - Gaborieau V
AU - Latimer C
AU - Thomas E
AU - Abnizova I
AU - Bucciarelli PE
AU - Jones D
AU - Teague JW
AU - Abediardekani B
AU - Serra S
AU - Scoazec JY
AU - Saffar H
AU - Azmoudehardalan F
AU - Sotoudeh M
AU - Nikmanesh A
AU - Poustchi H
AU - Niavarani A
AU - Gharavi S
AU - Eden M
AU - Richman P
AU - Campos LS
AU - Fitzgerald RC
AU - Ribeiro LF
AU - Soareslima SC
AU - Dzamalala C
AU - Mmbaga BT
AU - Shibata T
AU - Menya D
AU - Goldstein AM
AU - Hu N
AU - Malekzadeh R
AU - Fazel A
AU - Mccormack V
AU - Mckay J
AU - Perdomo S
AU - Scelo G
AU - Chanudet E
AU - Humphreys L
AU - Alexandrov LB
AU - Brennan P
AU - Stratton MR
TI - Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence
JO - Nature Genetics
VL - 53
IS - 11
SP - 1553
EP - 1563
PY - 2021
ER -

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