Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Autophagy, a Critical Element in the Aging Male Reproductive Disorders and Prostate Cancer: A Therapeutic Point of View Publisher Pubmed



Raee P1 ; Tan SC2 ; Najafi S3 ; Zandsalimi F4 ; Low TY2 ; Aghamiri S5, 6 ; Fazeli E7 ; Aghapour M8 ; Mofarahe ZS9 ; Heidari MH9 ; Fathabadi FF9 ; Abdi F10 ; Asouri M11 ; Ahmadi AA11 Show All Authors
Authors
  1. Raee P1
  2. Tan SC2
  3. Najafi S3
  4. Zandsalimi F4
  5. Low TY2
  6. Aghamiri S5, 6
  7. Fazeli E7
  8. Aghapour M8
  9. Mofarahe ZS9
  10. Heidari MH9
  11. Fathabadi FF9
  12. Abdi F10
  13. Asouri M11
  14. Ahmadi AA11
  15. Ghanbarian H3, 12
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  3. 3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19395-4719, Iran
  4. 4. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
  8. 8. Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany
  9. 9. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department of Chemical Engineering, Science and Research branch, Islamic Azad University, Tehran, Iran
  11. 11. North Research Center, Pasteur Institute of Iran, Amol, Iran
  12. 12. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Reproductive Biology and Endocrinology Published:2023


Abstract

Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely related to overall health and comorbidity in aging men. In this review, we will outline the role of autophagy as a new player in aging male reproductive dysfunction and prostate cancer. We first provide an overview of the mechanisms of autophagy and its role in regulating male reproductive cells. We then focus on the link between autophagy and aging-related diseases. This is followed by a discussion of therapeutic strategies targeting autophagy before we end with limitations of current studies and suggestions for future developments in the field. © 2023, BioMed Central Ltd., part of Springer Nature.
Related Docs
View other Related Docs
1. Targeting Autophagy in Prostate Cancer: Preclinical and Clinical Evidence for Therapeutic Response, Journal of Experimental and Clinical Cancer Research (2022)
2. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)
3. The Role of Autophagy in Cancer: From Molecular Mechanism to Therapeutic Window, Frontiers in Immunology (2025)
4. Autophagy: A Challengeable Paradox in Cancer Treatment, Cancer Medicine (2023)
5. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)
6. Regulation of Autophagy by Non-Coding Rnas in Human Glioblastoma, Medical Oncology (2024)
7. Nanotechnological Approaches in Prostate Cancer Therapy: Integration of Engineering and Biology, Nano Today (2022)
8. Virus, Exosome, and Microrna: New Insights Into Autophagy, Advances in Experimental Medicine and Biology (2022)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (4)
Mohsen Nikbakht (2)
Other Related Docs
9. Arsenic Trioxide Induction Autophagy in Human Acute Promyelocytic Leukemia, Koomesh (2018)
10. Oncolytic Paramyxoviruses-Induced Autophagy; a Prudent Weapon for Cancer Therapy, Journal of Biomedical Science (2019)
11. Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy, Cancer Treatment and Research Communications (2022)
12. Autophagy Induced by Metabolic Processes Leads to Solid Tumor Cell Metastatic Dormancy and Recurrence, Medical Oncology (2025)
13. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)
14. Antimicrobial Peptides: A Promising Strategy for Lung Cancer Drug Discovery?, Expert Opinion on Drug Discovery (2020)
15. Recent Advances in Sirna Delivery Systems for Prostate Cancer Therapy, Current Pharmaceutical Biotechnology (2022)
16. The Obesity-Autophagy-Cancer Axis: Mechanistic Insights and Therapeutic Perspectives, Seminars in Cancer Biology (2024)
17. Programmed Cell Death and Melatonin: A Comprehensive Review, Functional and Integrative Genomics (2024)
18. The Relationship Between Autophagy and Respiratory Viruses, Archives of Microbiology (2024)
19. Exosomes, Autophagy and Er Stress Pathways in Human Diseases: Cross-Regulation and Therapeutic Approaches, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)
20. Effect of a Freezing Medium Containing Melatonin on Markers of Pre-Meiotic and Post-Meiotic Spermatogonial Stem Cells (Sscs) After Transplantation in an Azoospermia Mouse Model Due to Testicular Torsion, Reproductive Sciences (2021)
21. Delivery of Genome Editing Tools: A Promising Strategy for Hpv-Related Cervical Malignancy Therapy, Expert Opinion on Drug Delivery (2020)
22. Paternal Exposure to Arsenic Resulted in Oxidative Stress, Autophagy, and Mitochondrial Impairments in the Hpg-S Axis of Pubertal Male Offspring, Chemosphere (2019)
23. Sperm Epigenetics and Male Infertility: Unraveling the Molecular Puzzle, Human Genomics (2024)
24. Metal-Based Nanoparticles in Cancer Therapy: Exploring Photodynamic Therapy and Its Interplay With Regulated Cell Death Pathways, International Journal of Pharmaceutics (2024)
25. Thermoluminescence Dosimetry of the Dose Received by Scrotum and Testes in Radiotherapy of Rectal Cancer, Compared to the Point Doses Calculated by 3D-Planning Software, Physica Medica (2018)
26. Effects of Different Autophagy Inhibitors on Sensitizing Kg-1 and Hl-60 Leukemia Cells to Chemotherapy, IUBMB Life (2021)
27. Combined Effects of High Fat Diet and Exercise on Autophagy in White Adipose Tissue of Mice, Life Sciences (2023)
28. Nonviral Sirna Delivery Systems for Pancreatic Cancer Therapy, Biotechnology and Bioengineering (2021)
29. The Association Between Consumption of Ultra-Processed Foods and Sperm Quality Parameters: A Cross-Sectional Study, BMC Research Notes (2025)
30. Role of Autophagy in the Pathogenesis of Rheumatoid Arthritis: Latest Evidence and Therapeutic Approaches, Life Sciences (2020)
31. Β Cell and Autophagy: What Do We Know?, Biomolecules (2023)
32. Targeting Ferroptosis in Gastrointestinal Tumors: Interplay of Iron-Dependent Cell Death and Autophagy, Molecular and Cellular Probes (2025)
33. Autophagy and Gastrointestinal Cancers: The Behind the Scenes Role of Long Non-Coding Rnas in Initiation, Progression, and Treatment Resistance, Cancer Gene Therapy (2021)
34. The Effect of Lactobacillus Crispatus and Lactobacillus Rhamnosus Culture Supernatants on Expression of Autophagy Genes and Hpv E6 and E7 Oncogenes in the Hela Cell Line, Cell Journal (2016)
35. Overcoming the Blood-Brain Barrier in Neurodegenerative Disorders and Brain Tumours, IET Nanobiotechnology (2020)
36. Anti-Proliferative and Apoptotic Effects of Valproic Acid on Hela Cells, International Journal of Cancer Management (2022)
37. Downward Trend in Male Reproductive Health and Fertility in Eastern Iran, Urologia Journal (2024)
38. Evaluation of Beclin1 and Mtor Genes and P62 Protein Expression in Breast Tumor Tissues of Iranian Patients, Molecular Biology Research Communications (2024)
39. Antimicrobial Peptides As Potential Therapeutics for Breast Cancer, Pharmacological Research (2021)
40. Autophagy Modulation in Breast Cancer Utilizing Nanomaterials and Nanoparticles, Frontiers in Oncology (2023)
41. Applications of Mesenchymal Stem Cells in Ocular Surface Diseases: Sources and Routes of Delivery, Expert Opinion on Biological Therapy (2023)
42. Micrornas Implications in the Onset, Diagnosis, and Prognosis of Osteosarcoma, Current Molecular Medicine (2021)
43. Crosstalk Between Autophagy and Metabolic Regulation of (Car) T Cells: Therapeutic Implications, Frontiers in Immunology (2023)
44. Therapeutic Effects of Resveratrol on Ischemia–Reperfusion Injury in the Nervous System, Neurochemical Research (2021)
45. Association Between Platelet, White Blood Cell Count, Platelet to White Blood Cell Ratio and Sarcopenia in Community-Dwelling Older Adults: Focus on Bushehr Elderly Health (Beh) Program, BMC Geriatrics (2022)
46. The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (Aml)?, International Journal of Hematology-Oncology and Stem Cell Research (2022)