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Functions, Mechanisms, and Clinical Applications of Lncrna Linc00857 in Cancer Pathogenesis Publisher Pubmed



Aldayyeni H1 ; Hjazi A2 ; Shahab S3 ; Gupta J4 ; Alsaab HO5 ; Motea YH6 ; Alazbjee AAA7 ; Romeroparra RM8 ; Obaid RF9 ; Hussien BM10 ; Hosseinifard SR11
Authors
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Authors Affiliations
  1. 1. Nottingham University Hospital, NHS Trust, Nottingham, United Kingdom
  2. 2. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  3. 3. Department of Business Administration, College of Business Administration, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia
  4. 4. Institute of Pharmaceutical Research, GLA University, Uttar Pradesh, Mathura, 281406, India
  5. 5. Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, 21944, Saudi Arabia
  6. 6. College of Dentistry, Al-Bayan University, Baghdad, Iraq
  7. 7. College of Medicine, Al-Ayen University, Thi-Qar, Nasiriyah, Iraq
  8. 8. Universidad Continental, Lima, Peru
  9. 9. Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq
  10. 10. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  11. 11. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Cell Published:2023


Abstract

Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial–mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications. © 2023, The Author(s) under exclusive licence to Japan Human Cell Society.
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