Tehran University of Medical Sciences

Science Communicator Platform

Share By
Recent Advances in Glioma Cancer Treatment: Conventional and Epigenetic Realms Publisher



Karami Fath M1 ; Babakhaniyan K2 ; Anjomrooz M3 ; Jalalifar M4 ; Alizadeh SD4 ; Pourghasem Z5 ; Abbasi Oshagh P6 ; Azargoonjahromi A7 ; Almasi F8 ; Manzoor HZ9 ; Khalesi B10 ; Pourzardosht N11 ; Khalili S12 ; Payandeh Z13
Authors

Source: Vaccines Published:2022


Abstract

Glioblastoma (GBM) is the most typical and aggressive form of primary brain tumor in adults, with a poor prognosis. Successful glioma treatment is hampered by ineffective medication distribution across the blood-brain barrier (BBB) and the emergence of drug resistance. Although a few FDA-approved multimodal treatments are available for glioblastoma, most patients still have poor prognoses. Targeting epigenetic variables, immunotherapy, gene therapy, and different vaccine- and peptide-based treatments are some innovative approaches to improve anti-glioma treatment efficacy. Following the identification of lymphatics in the central nervous system, immunotherapy offers a potential method with the potency to permeate the blood-brain barrier. This review will discuss the rationale, tactics, benefits, and drawbacks of current glioma therapy options in clinical and preclinical investigations. © 2022 by the authors.
Other Related Docs
9. Quercetin and Glioma: Which Signaling Pathways Are Involved?, Current Molecular Pharmacology (2022)
17. Pretreatment Evaluation of Glioma, Neuroimaging Clinics of North America (2016)