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Interleukin-10 But Not Transforming Growth Factor-Β1 Gene Expression Is Up-Regulated by Vitamin D Treatment in Multiple Publisher Pubmed



Farsani ZS1 ; Behmanesh M1 ; Sahraian MA2
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran
  2. 2. MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran

Source: Journal of the Neurological Sciences Published:2015


Abstract

Multiple sclerosis (MS) is an inflammatory and autoimmune disease. Variety of different genetics and environmental factors are involved in MS pathology. The epidemiological studies demonstrated that vitamin D has immune and immunomodulating effects on MS disease. Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1) genes in MS patients. We found that, the expression level of IL-10 gene in treated patients was up-regulated 3.84 times more than before treatment, but the expression level of TGF-β1 was not affected by vitamin D treatment. Also, a significant relationshipwas observed between vitamin D level and EDSS inMS patients. Our results indicated that the increased level of serum vitamin D and IL-10 gene expression may be associated with the reduction of EDSS scores in MS patients. © 2015 Elsevier B.V. All rights reserved.
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