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Experimental and Numerical Studies on Microfluidic Preparation and Engineering of Chitosan Nanoparticles Publisher



Soheili S1 ; Mandegar E2 ; Moradikhah F2 ; Doostitelgerd M3 ; Javar HA4
Authors
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Authors Affiliations
  1. 1. Department of Chemical Engineering, College of Engineering, University of Tehran, 111554563, Iran
  2. 2. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 1591634311, Iran
  3. 3. Cell Therapy and Regenerative Medicine Comprehensive Centre, Kerman University of Medical Sciences, Kerman, 7616913555, Iran
  4. 4. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Journal of Drug Delivery Science and Technology Published:2021


Abstract

Optimization of nanoparticle (NP) characteristics (e.g. size, shape, zeta potential, etc.) is essential to achieve desirable cell responses. In the current study, we intend to introduce an equation representing a prediction about hydrodynamic diameter of microfluidic (MF) preparation of chitosan-tripolyphosphate (CS-TPP) NPs as an influential factor on cell behavior. Both numerical simulation and experimental study have been employed for this study. TPP concentration, channel length and flow ratio (lateral flow to core flow) to find optimum mixing efficiency conditions using a computational fluid dynamics (CFD) in COMSOL 5.5 in a t-shaped MFD were evaluated numerically and consequently in experimental section, a cross-junction MFD was used for preparation of CS-TPP NPs based on optimum conditions obtained from numerical section to find a correlation between NPs hydrodynamic diameter, flow ratios and TPP concentrations. © 2020 Elsevier B.V.
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