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Aptamer-Functionalized Micelles for Targeted Cancer Therapy Publisher



Salahpouranarjan F1 ; Zare F2 ; Hosseini F3 ; Ahranjani SD4 ; Alipour M5 ; Gozali E6
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Faculty of Medicine, Aalborg University, Aalborg, Denmark
  3. 3. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Polymer Composite Research Laboratory, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  6. 6. Department of Health Information Technology, School of Allied Medical Sciences, Urmia University of Medical Sciences, Urmia, Iran

Source: Aptamers Engineered Nanocarriers for Cancer Therapy Published:2022


Abstract

Aptamers as molecular theranostic agents candidate are appropriate tools for diagnostics and therapeutic applications and basic research. They have been verified to have the potential for high affinity, targeting specificity, efficient internalization, and stable delivery of nanosystems carriers such micelles. Modified micelles with targeting moiety such as well-designed aptamers (Apt-micelles) are used as a drug/gene delivery system to enhance their selective delivery in target cells. Hence, Apt-micelles as an active targeting therapeutic system are being used to treat malignant diseases such as many types of cancers in precision medicine. This chapter represents an overview of recent developments of Apt-micelles in targeted cancer therapy. © 2023 Elsevier Ltd. All rights reserved.
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