Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles

Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles Publisher Pubmed

Taghdisi SM¹ ; Danesh NM^{2, 3} ; Lavaee P^{4, 5} ; Emrani AS⁶ ; Hassanabad KY⁷ ; Ramezani M² ; Abnous K⁸

Show Affiliations

1. Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3. Research Institute of Sciences and New Technology, Mashhad, Iran
4. Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran
5. Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran
6. Cardiovascular Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department of Infectious Disease, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran
8. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Materials Science and Engineering C Published:2016

Abstract

Clinical use of daunorubicin (Dau) in treatment of leukemia has been restricted because of its cardiotoxicity. Targeted delivery of anticancer drugs could decrease their off-target effects and enhance their efficacy. In this study a modified polyvalent aptamers (PA)-Daunorubicin (Dau)-Gold nanoparticles (AuNPs) complex was designed and its efficacy was assessed in Molt-4 cells (human acute lymphoblastic leukemia T-cell, target). Dau was efficiently loaded (10.5 μM) onto 1 mL of PA-modified AuNPs. Dau was released from the PA-Dau-AuNPs complex in a pH-sensitive manner (faster release at pH 5.5). The results of flow cytometry analysis indicated that the PA-Dau-AuNPs complex was efficiently internalized into target cells, but not into nontarget cells. The results of MTT assay were consistent with the internalization data. PA-Dau-AuNPs complex had less cytotoxicity in U266 cells compared to Dau alone and even Apt-Dau-AuNPs complex. The PA-Dau-AuNPs complex had more cytotoxicity in Molt-4 cells compared to Dau alone and even Apt-Dau-AuNPs complex. Cytotoxicity of PA-Dau-AuNPs complex was effectively antagonized using antisense of polyvalent aptamers. In conclusion, the designed drug delivery system inherited the properties of efficient drug loading, tumor targeting, pH-dependent drug release and controllable delivery of Dau to tumor cells. © 2016 Elsevier B.V. All rights reserved.

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Style	Citing Format
MLA	Taghdisi SM, et al.. "Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles." Materials Science and Engineering C, vol. 61, no. , 2016, pp. 753-761.
APA	Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, Abnous K (2016). Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles. Materials Science and Engineering C, 61(), 753-761.
Chicago	Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, Abnous K. "Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles." Materials Science and Engineering C 61, no. (2016): 753-761.
Harvard	Taghdisi SM et al. (2016) 'Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles', Materials Science and Engineering C, 61(), pp. 753-761.
Vancouver	Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, et al.. Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles. Materials Science and Engineering C. 2016;61():753-761.
BibTex	@article{ author = {Taghdisi SM and Danesh NM and Lavaee P and Emrani AS and Hassanabad KY and Ramezani M and Abnous K}, title = {Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles}, journal = {Materials Science and Engineering C}, volume = {61}, number = {}, pages = {753-761}, year = {2016} }
RIS	TY - JOUR AU - Taghdisi SM AU - Danesh NM AU - Lavaee P AU - Emrani AS AU - Hassanabad KY AU - Ramezani M AU - Abnous K TI - Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles JO - Materials Science and Engineering C VL - 61 IS - SP - 753 EP - 761 PY - 2016 ER -

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