Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Vitamin D Supplementation on Fibroblast Growth Factor-23 in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis Publisher Pubmed



Karimi E1 ; Bitarafan S2 ; Mousavi SM1 ; Zargarzadeh N3 ; Mokhtari P4 ; Hawkins J5 ; Meysamie A6 ; Koohdani F7, 8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, United States
  5. 5. Integrative Health, Franklin School of Integrative Health Sciences, Franklin, TN, United States
  6. 6. Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Phytotherapy Research Published:2021


Abstract

This is a meta-analysis of randomized controlled trials (RCTs) investigating the effects of oral vitamin D supplementation on serum fibroblast growth factor-23 (FGF23) concentrations in patients with chronic kidney disease (CKD). Manuscripts were extracted from PubMed/MEDLINE, Scopus, and ISI Web of Science through February 2020. Subgroup analyses, sensitivity analysis, and meta-regression assessments were performed. A total of eight clinical trials with nine treatment arms were included in the final analysis. The pooled results showed no significant changes in circulating FGF23 following vitamin D supplementation compared to the control group (Standardized mean difference (SMD): 0.24; 95% confidence intervals (CIs): −0.03 to 0.50, p > 0.05). Subgroup analyses found that studies which had participants with a body mass index (BMI) higher than 25 kg/m2, with an intervention duration shorter than 15 weeks, using phosphate binder medications, and trials that were on both patients with CKD undergoing hemodialysis and patients without hemodialysis treatment produced significant increases in FGF23 when concentration compared with the control group. This meta-analysis provides evidence that vitamin D supplementation does not have a significant effect on plasma FGF23 levels. However, further high-quality trials are required to identify the influence of oral vitamin D supplementation on FGF23 levels in patients with CKD. © 2021 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. The Effects of Vitamin D Treatment on Glycemic Control, Serum Lipid Profiles, and C-Reactive Protein in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, International Urology and Nephrology (2019)
2. Almond Supplementation on Appetite Measures, Body Weight, and Body Composition in Adults: A Systematic Review and Dose-Response Meta-Analysis of 37 Randomized Controlled Trials, Obesity Reviews (2024)
3. The Association of Fibroblast Growth Factor-23 With Mineral Factors (Ca, P, and Mg), Parathyroid Hormone, and 25-Hydroxyvitamin D in Hemodialysis Patients: A Multicenter Study, Nephro-Urology Monthly (2018)
4. The Effects of Curcumin Supplementation on Body Weight, Body Mass Index and Waist Circumference: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Critical Reviews in Food Science and Nutrition (2020)
5. Comparison of the Effect of a Low-Carbohydrate Diet With a Low-Fat Diet on Anthropometric Indices and Body Fat Percentage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Nutrition and Food Security (2023)
6. Impact of Omega-3 Supplementation on Homocysteine Levels in Humans: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials, Nutrition# Metabolism and Cardiovascular Diseases (2022)
7. Appropriate Interventions for Pregnant Women With Indicators of Metabolic Syndrome on Pregnancy Outcomes: A Systematic Review, International Journal of Preventive Medicine (2019)
8. Meal Replacements on Obesity and Leptin: A Systematic Review and Meta-Analysis, Reviews in Endocrine and Metabolic Disorders (2025)
Experts (# of related papers)
View all Related Experts
Pejman Rohani (11)
Kurosh Djafarian (5)
Other Related Docs
9. The Effectiveness of Telehealth Interventions for People With Multiple Sclerosis: A Systematic Review and Meta-Analysis Protocol, Digital Health (2023)
10. Effects of Cereal Beta-Glucan Consumption on Body Weight, Body Mass Index, Waist Circumference and Total Energy Intake: A Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2019)
11. Effect of Nigella Sativa Supplementation on Obesity Indices: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2018)
12. The Effect of Statin Therapy in Combination With Ezetimibe on Circulating C-Reactive Protein Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Inflammopharmacology (2022)
13. Effects of Saffron (Crocus Sativus L.) Supplementation on Inflammatory Biomarkers: A Systematic Review and Meta-Analysis, Phytotherapy Research (2021)
14. The Effect of Apple Cider Vinegar on Lipid Profiles and Glycemic Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, BMC Complementary Medicine and Therapies (2021)
15. Effects of Sesame Consumption on Inflammatory Biomarkers in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Evidence-based Complementary and Alternative Medicine (2021)
16. Effect of Vitamin E Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis, Journal of Human Hypertension (2019)
17. The Effect of Chromium Supplementation on Apolipoproteins: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition ESPEN (2020)
18. Short-Term Ambient Temperature Variations and Incidence of Preterm Birth: A Systematic Review and Meta-Analysis, International Journal of Hygiene and Environmental Health (2024)
19. Effectiveness of Dry Needling for Improving Pain and Disability in Adults With Tension-Type, Cervicogenic, or Migraine Headaches: Protocol for a Systematic Review, Chiropractic and Manual Therapies (2019)
20. The Effects of Subcutaneous Tirzepatide on Obesity and Overweight: A Systematic Review and Meta‐Regression Analysis of Randomized Controlled Trials, Frontiers in Endocrinology (2023)
21. Hepatitis C Infection Seroprevalence in Pregnant Women Worldwide: A Systematic Review and Meta-Analysis, eClinicalMedicine (2023)
22. “Begging the Question”—Does Toxocara Infection/Exposure Associate With Multiple Sclerosis-Risk?, Pathogens (2020)
23. Effectiveness and Safety of Azvudine in Covid-19: A Systematic Review and Meta-Analysis, PLoS ONE (2024)
24. Effect of Avena Sativa (Oats) on Cognitive Function: A Systematic Review of Randomized Controlled Trials, Clinical Nutrition ESPEN (2023)
25. The Effect of Saffron on Weight and Lipid Profile: A Systematic Review, Meta-Analysis, and Dose–Response of Randomized Clinical Trials, Phytotherapy Research (2019)
26. The Effects of Beinaglutide on Obesity and Related Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Expert Review of Endocrinology and Metabolism (2025)
27. Prevalence of Gram-Negative Bacteria in Ventilator-Associated Pneumonia in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis Protocol, BMJ Open (2016)
28. Oral Nutritional Supplementation in Cancer Patients: A Systematic Review and Dose–Response Meta-Analysis, Clinical Nutrition (2025)
29. Efficacy of Photobiomodulation Therapy on Neurosensory Recovery in Patients With Inferior Alveolar Nerve Injury Following Oral Surgical Procedures: A Systematic Review, Quintessence International (2021)
30. Effects of Grape Products on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
31. Effect of Soluble Fiber on Blood Pressure in Adults: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Nutrition Journal (2023)
32. Visceral Obesity and Its Shared Role in Cancer and Cardiovascular Disease: A Scoping Review of the Pathophysiology and Pharmacological Treatments, International Journal of Molecular Sciences (2020)
33. Does Infant Formula Containing Synbiotics Support Adequate Growth in Infants? a Meta-Analysis and Systematic Review of Randomized Controlled Trials, Critical Reviews in Food Science and Nutrition (2023)
34. Ginger Intervention on Body Weight and Body Composition in Adults: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of 27 Randomized Controlled Trials, Nutrition Reviews (2024)
35. The Effect of Metformin on Adipokines Levels: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials, Diabetes Research and Clinical Practice (2024)
36. Effects of Protein and Amino Acid Supplementation on Muscle Mass and Strength in a Healthy Population, Nutrition Today (2022)
37. Meta-Analysis: Efficacy of Exclusive Enteral Nutrition As Induction Therapy on Disease Activity Index, Inflammation and Growth Factors in Paediatric Crohn’S Disease, Alimentary Pharmacology and Therapeutics (2022)
38. The Long-Term Effect of Exposure to Respirable Particulate Matter on the Incidence of Myocardial Infarction: A Systematic Review and Meta-Analysis Study, Environmental Science and Pollution Research (2022)
39. The Effect of Meal Replacements Therapy on Blood Pressure and C-Reactive Protein: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Hypertension (2025)
40. Demineralized Bone Matrix in Anterior Cervical Discectomy and Fusion: A Systematic Review, European Spine Journal (2017)
41. The Effects of Conjugated Linoleic Acid Supplementation on Anthropometrics and Body Composition Indices in Adults: A Systematic Review and Dose-Response Meta-Analysis, British Journal of Nutrition (2024)
42. Association of Wrist Circumference With Cardio-Metabolic Risk Factors: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2020)
43. The Effects of Bupropion Alone and Combined With Naltrexone on Weight Loss: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials, Diabetology and Metabolic Syndrome (2024)
44. Changes in Serum Brain-Derived Neurotrophic Factor Following Supplementation of Omega 3 Fatty Acids: A Systematic Review and Meta-Regression Analysis, Clinical Nutrition ESPEN (2023)
45. A Systematic Review and Meta-Analysis on the Impact of Oral Vitamin E Supplementation on Apolipoproteins A1 and B100, Clinical Nutrition ESPEN (2021)
46. Clinical Safety and Efficacy of Bispecific Antibody in the Treatment of Solid Tumors: A Protocol for a Systematic Review, PLoS ONE (2022)
47. A Comprehensive Review and Meta-Regression Analysis of Randomized Controlled Trials Examining the Impact of Vitamin B12 Supplementation on Homocysteine Levels, Nutrition Reviews (2024)
48. Comparing the Effects of Docosahexaenoic and Eicosapentaenoic Acids on Cardiovascular Risk Factors: Pairwise and Network Meta-Analyses of Randomized Controlled Trials, Nutrition# Metabolism and Cardiovascular Diseases (2023)
49. Relationship Between Low-Density Lipoprotein Cholesterol, Lipid-Lowering Agents and Risk of Stroke: A Meta-Analysis of Observational Studies (N = 355,591) and Randomized Controlled Trials (N = 165,988), Archives of Medical Science (2022)
50. Egg Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies, Advances in Nutrition (2022)