Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors

Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors Publisher

Kaviani R¹ ; Saeedi M^{2, 3} ; Mahdavi M⁴ ; Nadri H⁵ ; Moradi A⁵ ; Shafiee A⁶ ; Akbarzadeh T^{3, 7}

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Turkish Journal of Chemistry Published:2017

Abstract

Novel derivatives of chromenone bearing an N-carbamothioyl moiety were synthesized and evaluated for their soybean 15-LOX inhibitory activity. Synthesis of the target compounds was started from 7-hydroxy-2H-chromen-2-one. It was reacted with 1-fluoro-2(4)-nitrobenzene to obtain the corresponding nitrophenoxy-chromenone derivative. Reduction of the nitro group was achieved in the presence of Zn/NH4Cl and reaction of the latter compound with in situ prepared benzoyl isothiocyanate led to the formation of the title compounds. All compounds were characterized and tested against soybean 15-LOX. Among them, 4-methyl-N-((4-((2-oxo-2H-chromen-7-yl)oxy)phenyl)carbamothioyl)benzamide (7l) showed the best activity as potent as the reference drug, quercetin. © TUBITAK.

Style	Citing Format
MLA	Kaviani R, et al.. "Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors." Turkish Journal of Chemistry, vol. 41, no. 3, 2017, pp. 335-344.
APA	Kaviani R, Saeedi M, Mahdavi M, Nadri H, Moradi A, Shafiee A, Akbarzadeh T (2017). Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors. Turkish Journal of Chemistry, 41(3), 335-344.
Chicago	Kaviani R, Saeedi M, Mahdavi M, Nadri H, Moradi A, Shafiee A, Akbarzadeh T. "Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors." Turkish Journal of Chemistry 41, no. 3 (2017): 335-344.
Harvard	Kaviani R et al. (2017) 'Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors', Turkish Journal of Chemistry, 41(3), pp. 335-344.
Vancouver	Kaviani R, Saeedi M, Mahdavi M, Nadri H, Moradi A, Shafiee A, et al.. Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors. Turkish Journal of Chemistry. 2017;41(3):335-344.
BibTex	@article{ author = {Kaviani R and Saeedi M and Mahdavi M and Nadri H and Moradi A and Shafiee A and Akbarzadeh T}, title = {Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors}, journal = {Turkish Journal of Chemistry}, volume = {41}, number = {3}, pages = {335-344}, year = {2017} }
RIS	TY - JOUR AU - Kaviani R AU - Saeedi M AU - Mahdavi M AU - Nadri H AU - Moradi A AU - Shafiee A AU - Akbarzadeh T TI - Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors JO - Turkish Journal of Chemistry VL - 41 IS - 3 SP - 335 EP - 344 PY - 2017 ER -

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