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When Size Matters: Biological Response to Strontium- and Cobalt-Substituted Bioactive Glass Particles Publisher



Kargozar S1 ; Baino F2 ; Lotfibakhshaiesh N3 ; Hill RG4 ; Milan PB5 ; Hamzehlou S6 ; Joghataei MT7 ; Mozafari M8
Authors
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Authors Affiliations
  1. 1. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Institute of Materials Physics and Engineering, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Torino, Italy
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Unit of Dental Physical Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom
  5. 5. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran

Source: Materials Today: Proceedings Published:2018


Abstract

In this study, the biological effects of two different particle sizes of strontium- and cobalt-substituted bioactive glasses (BGs) were compared to reveal the particle size effect. For this aim, the dissolution products of the BG particles with the mean diameter of 9 and 725 μm were added to cell culture media of osteosarcoma cell line SaOS-2. The results of alkaline phosphatase activity assay, alizarin red staining, and real time PCR showed that the smaller particles (9 μm) can be more effective than the larger ones (725 μm) in terms of osteogenesis and angiogenesis. However, 9-micron particles had higher cytotoxicity than the 725-μm samples. © 2018 Elsevier Ltd.
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