The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia

The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia Publisher Pubmed

Yousefi M^{1, 2} ; Movassaghpour AA² ; Shamsasenjan K² ; Ghalamfarsa G³ ; Sadreddini S¹ ; Jadidiniaragh F⁴ ; Hojjatfarsangi M⁵

Source: Future Oncology Published:2015

Abstract

While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic conditions such as autoimmune and cancer diseases. B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the western world and is characterized with monoclonal expansion of B lymphocytes. There is evidence which implies that the progression of CLL is associated with expansion of Treg and downregulation of Th17 cells. In this review, we will discuss about immunobiology of Treg and Th17 cells and their role in immunopathogenesis of CLL as well as their reciprocal changes during disease progression. © 2015 Future Medicine Ltd.

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Style	Citing Format
MLA	Yousefi M, et al.. "The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia." Future Oncology, vol. 11, no. 10, 2015, pp. 1567-1582.
APA	Yousefi M, Movassaghpour AA, Shamsasenjan K, Ghalamfarsa G, Sadreddini S, Jadidiniaragh F, Hojjatfarsangi M (2015). The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia. Future Oncology, 11(10), 1567-1582.
Chicago	Yousefi M, Movassaghpour AA, Shamsasenjan K, Ghalamfarsa G, Sadreddini S, Jadidiniaragh F, Hojjatfarsangi M. "The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia." Future Oncology 11, no. 10 (2015): 1567-1582.
Harvard	Yousefi M et al. (2015) 'The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia', Future Oncology, 11(10), pp. 1567-1582.
Vancouver	Yousefi M, Movassaghpour AA, Shamsasenjan K, Ghalamfarsa G, Sadreddini S, Jadidiniaragh F, et al.. The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia. Future Oncology. 2015;11(10):1567-1582.
BibTex	@article{ author = {Yousefi M and Movassaghpour AA and Shamsasenjan K and Ghalamfarsa G and Sadreddini S and Jadidiniaragh F and Hojjatfarsangi M}, title = {The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia}, journal = {Future Oncology}, volume = {11}, number = {10}, pages = {1567-1582}, year = {2015} }
RIS	TY - JOUR AU - Yousefi M AU - Movassaghpour AA AU - Shamsasenjan K AU - Ghalamfarsa G AU - Sadreddini S AU - Jadidiniaragh F AU - Hojjatfarsangi M TI - The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia JO - Future Oncology VL - 11 IS - 10 SP - 1567 EP - 1582 PY - 2015 ER -

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