Peptidomimetics in Cancer Targeting Publisher Pubmed



Gomari MM¹ ; Abkhiz S¹ ; Pour TG² ; Lotfi E¹ ; Rostami N³ ; Monfared FN⁴ ; Ghobari B⁵ ; Mosavi M¹ ; Alipour B⁶ ; Dokholyan NV^{7, 8}
Source: Molecular Medicine Published:2022

Abstract

The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy production compared to proteins are highly regarded in designing cancer vaccines and oncogenic pathway inhibitors. Although peptides seem to be a suitable therapeutic option, their short lifespan, instability, and low binding affinity for their target have not been widely applicable against malignant tumors. Given the peptides’ disadvantages, a new class of agents called peptidomimetic has been introduced. With advances in physical chemistry and biochemistry, as well as increased knowledge about biomolecule structures, it is now possible to chemically modify peptides to develop efficient peptidomimetics. In recent years, numerous studies have been performed to the evaluation of the effectiveness of peptidomimetics in inhibiting metastasis, angiogenesis, and cancerous cell growth. Here, we offer a comprehensive review of designed peptidomimetics to diagnose and treat cancer. © 2022, The Author(s).