Nanoparticulate Systems for Dental Drug Delivery Publisher



Koopaie M¹
Source: Nanoengineered Biomaterials for Advanced Drug Delivery Published:2020

Abstract

Nanoparticles (NPs) have a great potential to be ideal carriers for delivering therapeutics to diseased sites with minimal collateral damage to normal tissues. In nanoparticulate systems, drugs are dissolved, entrapped, encapsulated, or attached to a nanoparticle matrix. Nanoparticles have controlled release rate and stability in sites of diseases. In this chapter, nanoparticulate systems for dental drug delivery, about three main oral complications of the oral cavity including dental caries, periodontal disease, and oral cancer were discussed. The role of liposomes, polymeric micelles, polymeric nanoparticles, carbon-based nanoparticles, nanohydroxyapatite, iron oxide, zirconia, silica, and silver nanoparticles was reviewed in dental caries as a most common infectious disease in human being. In the next section, using liposomes and nanofibers for periodontal treatment was studied. Furthermore, nanoparticles including liposomes, gold nanoparticles, hydrogels, liquid crystals (LC), and cyclodextrin in diagnosis, prevention, and the treatment of the oral cavity were studied. Photosensitizer nanoparticles as an oral anticancer delivery system in photodynamic treatment were reviewed. © 2020 Elsevier Ltd All rights reserved.