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Pediatric Acute Lymphoblastic Leukemia Management Using Multitargeting Bioactive Natural Compounds: A Systematic and Critical Review Publisher Pubmed



Nabizadeh F1 ; Momtaz S2, 3 ; Ghanbarimovahed M1 ; Qalekhani F1, 4 ; Mohsenpour H5 ; Aneva IY6 ; Bishayee A7 ; Farzaei MH1 ; Bishayee A7
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Health Technologies Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  2. 2. Medicinal Plants Research Center, Institute of Medicinal Plants, Karaj, 141554364, Iran
  3. 3. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, and Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  4. 4. Medical Biology Research Center, Health Technologies Institute, Kermanshah University of Medical Sciences, Kermanshah, 6714415185, Iran
  5. 5. Department of Pediatrics, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, 6742775333, Iran
  6. 6. Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria
  7. 7. Pine View School, Osprey, 34229, FL, United States
  8. 8. College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, 34211, FL, United States

Source: Pharmacological Research Published:2022


Abstract

Pediatric acute lymphoblastic leukemia (pALL), a malignancy of the lymphoid line of blood cells, accounts for a large percentage of all childhood leukemia cases. Although the 5-year survival rate for children with ALL has greatly improved over years, using chemotherapeutics as its first-line treatment still causes short- and long-term side effects. Furthermore, induction of toxicity and resistance, as well as the high cost, limit their application. Phytochemicals, with remarkable cancer preventive and chemotherapeutic characteristics, may serve as old solutions to new challenges. Bioactive plant secondary metabolites have exhibited promising antileukemic and adjunctive effects by targeting various molecular processes, including autophagy, cell cycle, angiogenesis, and extrinsic/intrinsic apoptotic pathways. Although numerous reports have shown that various plant secondary metabolites can interfere with the progression of malignancies, including leukemia, there was no comprehensive review article on the effect of phytochemicals on pALL. This systematic review aims to provide critical and cohesive analysis of the potential of various naturally-occurring plant secondary metabolites in the management of pALL with the understanding of underlying molecular and cellular mechanisms of action. © 2022 Elsevier Ltd