Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function

Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function Publisher Pubmed

Sahebnasagh A¹ ; Hashemi J² ; Khoshi A³ ; Saghafi F⁴ ; Avan R⁵ ; Faramarzi F⁶ ; Azimi S⁷ ; Habtemariam S⁸ ; Sureda A^{9, 10} ; Khayatkashani M¹¹ ; Safdari M¹² ; Rezai Ghaleno H¹³ ; Soltani H¹⁴ ; Khayat Kashani HR¹⁵

Show Affiliations

1. Clinical Research Center, Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
2. Department of Pathobiology and Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3. Department of Clinical Biochemistry, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4. Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5. Assistant Professor of Clinical Pharmacy, Department of Clinical Pharmacy, Medical Toxicology and Drug Abuse Research Center (MTDRC), Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
6. Clinical Pharmacy Research Center, Iran University of Medical Sciences, Tehran, Iran
7. Student Research Committee, Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Pharmacognosy Research Laboratories and Herbal Analysis Services, School of Science, University of Greenwich, Central Avenue, Chatham-Maritime, Kent, ME4 4TB, United Kingdom
9. Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands and Health Research Institute of Balearic Islands (IdISBa), Palma de Mallorca, Spain
10. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
11. School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, 14155-6559, Iran
12. Department of Orthopedic Surgery, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
13. Department of Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
14. Department of General Surgery, Imam Ali Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran
15. Department of Neurosurgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Mitochondrion Published:2021

Abstract

Mitochondria are ubiquitous membrane-bound organelles that not only play a key role in maintaining cellular energy homeostasis and metabolism but also in signaling and apoptosis. Aryl hydrocarbons receptors (AhRs) are ligand-activated transcription factors that recognize a wide variety of xenobiotics, including polyaromatic hydrocarbons and dioxins, and activate diverse detoxification pathways. These receptors are also activated by natural dietary compounds and endogenous metabolites. In addition, AhRs can modulate the expression of a diverse array of genes related to mitochondrial biogenesis and function. The aim of the present review is to analyze scientific data available on the AhR signaling pathway and its interaction with the intracellular signaling pathways involved in mitochondrial functions, especially those related to cell cycle progression and apoptosis. Various evidence have reported the crosstalk between the AhR signaling pathway and the nuclear factor κB (NF-κB), tyrosine kinase receptor signaling and mitogen-activated protein kinases (MAPKs). The AhR signaling pathway seems to promote cell cycle progression in the absence of exogenous ligands, whereas the presence of exogenous ligands induces cell cycle arrest. However, its effects on apoptosis are controversial since activation or overexpression of AhR has been observed to induce or inhibit apoptosis depending on the cell type. Regarding the mitochondria, although activation by endogenous ligands is related to mitochondrial dysfunction, the effects of endogenous ligands are not well understood but point towards antiapoptotic effects and inducers of mitochondrial biogenesis. © 2021 Elsevier B.V. and Mitochondria Research Society

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Style	Citing Format
MLA	Sahebnasagh A, et al.. "Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function." Mitochondrion, vol. 61, no. , 2021, pp. 85-101.
APA	Sahebnasagh A, Hashemi J, Khoshi A, Saghafi F, Avan R, Faramarzi F, Azimi S, Habtemariam S, Sureda A, Khayatkashani M, Safdari M, Rezai Ghaleno H, Soltani H, Khayat Kashani HR (2021). Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function. Mitochondrion, 61(), 85-101.
Chicago	Sahebnasagh A, Hashemi J, Khoshi A, Saghafi F, Avan R, Faramarzi F, Azimi S, et al.. "Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function." Mitochondrion 61, no. (2021): 85-101.
Harvard	Sahebnasagh A et al. (2021) 'Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function', Mitochondrion, 61(), pp. 85-101.
Vancouver	Sahebnasagh A, Hashemi J, Khoshi A, Saghafi F, Avan R, Faramarzi F, et al.. Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function. Mitochondrion. 2021;61():85-101.
BibTex	@article{ author = {Sahebnasagh A and Hashemi J and Khoshi A and Saghafi F and Avan R and Faramarzi F and Azimi S and Habtemariam S and Sureda A and Khayatkashani M and Safdari M and Rezai Ghaleno H and Soltani H and Khayat Kashani HR}, title = {Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function}, journal = {Mitochondrion}, volume = {61}, number = {}, pages = {85-101}, year = {2021} }
RIS	TY - JOUR AU - Sahebnasagh A AU - Hashemi J AU - Khoshi A AU - Saghafi F AU - Avan R AU - Faramarzi F AU - Azimi S AU - Habtemariam S AU - Sureda A AU - Khayatkashani M AU - Safdari M AU - Rezai Ghaleno H AU - Soltani H AU - Khayat Kashani HR TI - Aromatic Hydrocarbon Receptors in Mitochondrial Biogenesis and Function JO - Mitochondrion VL - 61 IS - SP - 85 EP - 101 PY - 2021 ER -

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