Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Therapeutic Effects of Mesenchymal Stem Cells-Derived Extracellular Vesicles’ Mirnas on Retinal Regeneration: A Review Publisher Pubmed



Rajool Dezfuly A1 ; Safaee A1 ; Salehi H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Stem Cell Research and Therapy Published:2021


Abstract

Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted from all cells to transform vital information in the form of lipids, proteins, mRNAs and small RNAs such as microRNAs (miRNAs). Many studies demonstrated that EVs’ miRNAs have effects on target cells. Numerous people suffer from the blindness caused by retinal degenerations. The death of retinal neurons is irreversible and creates permanent damage to the retina. In the absence of acceptable cures for retinal degenerative diseases, stem cells and their paracrine agents including EVs have become a promising therapeutic approach. Several studies showed that the therapeutic effects of stem cells are due to the miRNAs of their EVs. Considering the effects of microRNAs in retinal cells development and function and studies which provide the possible roles of mesenchymal stem cells-derived EVs miRNA content on retinal diseases, we focused on the similarities between these two groups of miRNAs that could be helpful for promoting new therapeutic techniques for retinal degenerative diseases. © 2021, The Author(s).
Related Docs
View other Related Docs
1. Overview of Retinal Differentiation Potential of Mesenchymal Stem Cells: A Promising Approach for Retinal Cell Therapy, Annals of Anatomy (2017)
2. Therapeutic Effects of Human Adipose Mesenchymal Stem Cells and Their Paracrine Agents on Sodium Iodate Induced Retinal Degeneration in Rats, Life Sciences (2022)
3. Pathological Role of Inflammation in Ocular Disease Progress and Its Targeting by Mesenchymal Stem Cells (Mscs) and Their Exosome; Current Status and Prospect, Pathology Research and Practice (2023)
4. The Role of Mirnas From Mesenchymal Stem/Stromal Cells-Derived Extracellular Vesicles in Neurological Disorders, Human Cell (2023)
5. Microrna-100 Shuttled by Mesenchymal Stem Cell-Derived Exosomes Suppresses in Vitro Angiogenesis Through Modulating the Mtor/Hif-1Α/Vegf Signaling Axis in Breast Cancer Cells, Cellular Oncology (2017)
6. Host and Pathogen-Directed Therapies Against Microbial Infections Using Exosome- and Antimicrobial Peptide-Derived Stem Cells With a Special Look at Pulmonary Infections and Sepsis, Stem Cell Reviews and Reports (2023)
7. Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors, Progress in Biophysics and Molecular Biology (2023)
8. Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes As a Cell-Free Therapy Approach for the Treatment of Skin, Bone, and Cartilage Defects, Connective Tissue Research (2022)
Experts (# of related papers)
View all Related Experts
Hossein Salehi (7)
Mohammad Kazemi (5)
Other Related Docs
9. Differentiation of Eye Field Neuroectoderm From Human Adipose-Derived Stem Cells by Using Small-Molecules and Hadsc-Conditioned Medium, Annals of Anatomy (2019)
10. Unveiling Mesenchymal Stem Cells’ Regenerative Potential in Clinical Applications: Insights in Mirna and Lncrna Implications, Cells (2023)
11. The Therapeutic Potential of Human Umbilical Cord Mesenchymal Stromal Cells Derived Exosomes for Wound Healing: Harnessing Exosomes As a Cell-Free Therapy, Journal of Stem Cells and Regenerative Medicine (2024)
12. Emerging Role of Mesenchymal Stem/Stromal Cells (Mscs) and Mscs-Derived Exosomes in Bone- and Joint-Associated Musculoskeletal Disorders: A New Frontier, European Journal of Medical Research (2023)
13. The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential, Cellular and Molecular Neurobiology (2024)
14. Combination Therapy of Stem Cell-Derived Exosomes and Biomaterials in the Wound Healing, Stem Cell Reviews and Reports (2022)
15. Comparison of the Expression of Mir-326 Between Interferon Beta Responders and Non-Responders in Relapsing-Remitting Multiple Sclerosis, Cell Journal (2020)
16. Msc-Derived Exosomes Enhance the Anticancer Activity of Drugs in 3D Spheroid of Breast Cancer Cells, Journal of Drug Delivery Science and Technology (2024)
17. Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Multiple Sclerosis Disease, Applied Nanoscience (Switzerland) (2023)
18. Exploring the Role of Exosomes in Diabetic Neuropathy: From Molecular Mechanisms to Therapeutic Potential, Biomedicine and Pharmacotherapy (2025)
19. Human Adipose Derived Stem Cell Exosomes Enhance the Neural Differentiation of Pc12 Cells, Molecular Biology Reports (2021)
20. Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Perianal Fistula in Non-Crohn's Cases: Clinical Trial Phase I, Journal of Gastroenterology and Hepatology (Australia) (2023)
21. Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy, Immunological Investigations (2020)
22. Current Advances in Stem Cell Therapy in the Treatment of Multiple Sclerosis, Reviews in the Neurosciences (2023)
23. Microrna: Relevance to Stroke Diagnosis, Prognosis, and Therapy, Journal of Cellular Physiology (2018)
24. Epigenetic Regulation in Myocardial Infarction: Non-Coding Rnas and Exosomal Non-Coding Rnas, Frontiers in Cardiovascular Medicine (2022)
25. Engineered Small Extracellular Vesicles As a Novel Platform to Suppress Human Oncovirus-Associated Cancers, Infectious Agents and Cancer (2023)
26. Current Knowledge of Immunomodulation Strategies for Chronic Skin Wound Repair, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2022)
27. Exosomes and Micrornas: New Potential Therapeutic Candidates in Alzheimer Disease Therapy, Journal of Cellular Physiology (2019)
28. The Role of Micrornas Involved in the Disorder of Blood–Brain Barrier in the Pathogenesis of Multiple Sclerosis, Frontiers in Immunology (2023)
29. Exosomes As Therapeutic and Drug Delivery Vehicle for Neurodegenerative Diseases, Journal of Nanobiotechnology (2024)
30. Long Non-Coding Rnas Involved in Retinoblastoma, Journal of Cancer Research and Clinical Oncology (2023)
31. The Therapeutic Effect of Mscs and Their Extracellular Vesicles on Neuroblastoma, Progress in Biophysics and Molecular Biology (2024)
32. Mesenchymal Stem/Stromal (Mscs)-Derived Exosome Inhibits Retinoblastoma Y-79 Cell Line Proliferation and Induces Their Apoptosis, Nanomedicine Research Journal (2022)
33. Exosomal Mirnas As Novel Cancer Biomarkers: Challenges and Opportunities, Journal of Cellular Physiology (2018)
34. In Vitro Augmentation of Mesenchymal Stem Cells Viability in Stressful Microenvironments: In Vitro Augmentation of Mesenchymal Stem Cells Viability, Cell Stress and Chaperones (2015)
35. Hypoxia-Preconditioned Wj-Msc Spheroid-Derived Exosomes Delivering Mir-210 for Renal Cell Restoration in Hypoxia-Reoxygenation Injury, Stem Cell Research and Therapy (2024)
36. The Role of Transcription Factors in Regulating the Development and Differentiation of Neural Retina Cells, Journal of Isfahan Medical School (2015)
37. Micrornas: Key Modulators of Disease-Modifying Therapies in Multiple Sclerosis : Pancreatic Cancer Is One of the Lethal Malignant Tumours in the World.In This Study, We Investigated the Car T-Cell Therapy of Pancreatic Cancer, International Reviews of Immunology (2020)
38. Differentiation of Human Embryonic Stem Cell-Derived Retinal Progenitors Into Retinal Cells by Sonic Hedgehog And/Or Retinal Pigmented Epithelium and Transplantation Into the Subretinal Space of Sodium Iodate-Injected Rabbits, Stem Cells and Development (2012)
39. The Effect of Dental Stem Cell Conditioned Medium on the Thickness of the Damaged Retina in Rat, Journal of Isfahan Medical School (2022)
40. Stem Cell-Derived Nano-Scale Vesicles Promotes the Proliferation of Retinal Ganglion Cells (Rgcs) by Activation Pi3k/Akt and Erk Pathway, Nanomedicine Research Journal (2022)
41. Micro-Rnas As Critical Regulators of Matrix Metalloproteinases in Cancer, Journal of Cellular Biochemistry (2018)
42. Glutathione Targeted Tragacanthic Acid-Chitosan As a Non-Viral Vector for Brain Delivery of Mirna-219A-5P: An in Vitro/In Vivo Study, International Journal of Biological Macromolecules (2022)
43. Application of Hanging Drop Culture for Retinal Precursor-Like Cells Differentiation of Human Adipose-Derived Stem Cells Using Small Molecules, Journal of Molecular Neuroscience (2019)
44. Exosomes and Non-Coding Rnas: Exploring Their Roles in Human Myocardial Dysfunction, Biomedicine and Pharmacotherapy (2025)