Systematic Review and Meta-Analysis on the Prevalence and Antibiotic Susceptibility Pattern in Pseudomonas Aeruginosa Isolated From Cystic Fibrosis Patients Publisher

Summary: A review in the Middle East found P. aeruginosa affects about 1 in 3 cystic fibrosis patients. Research suggests colistin and ticarcillin remain most effective, but resistance is high. #CysticFibrosis #AntibioticResistance

Rastegarkashkouli A¹ ; Khaledi A² ; Moammer F³ ; Ghenaatpisheh Sanani M⁴ ; Heidari MM⁵ ; Foroughi Eghbal A⁶
Source: Eurasian Journal of Medicine Published:2024

Abstract

This study aimed to conduct a retrospective Middle East systematic review and meta-analysis on the prevalence and antibiotic susceptibility pattern for this microorganism isolated from cystic fibrosis patients. We searched MEDLINE, the Cochrane Library, SCOPUS, and Web of Science (ISI) to identify studies that reported the prevalence of Pseudomonas aeruginosa isolated from cystic fibrosis (CF) patients, and antibiotic resistance patterns. To assess the quality of publications was used of a checklist provided by the Joanna Briggs Institute. Finally, the data was analyzed by comprehensive meta-analysis software. The studied populations comprised children and young, and adult CF patients. Patients were aged between 3 months-65 years. A higher percentage of CF patients were males. Pseudomonas aeruginosa frequency varied between 5.9 and 76.2% in the studies included. The combined prevalence of P. aeruginosa was reported 34.3%. The lowest level resistance of P. aeruginosa was toward colistin (0%-13.3%) and ticarcillin (3.9%-24%). Our study showed the prevalence of P. aeruginosa and antibiotic resistance are almost high, while colistin and ticarcillin are the best antibiotics to decrease postantibiotic effects (PAEs) in CF patients from the Middle East. Therefore, physicians should pay more attention to therapeutic protocols to prevent further resistance. © 2024, AVES. All rights reserved.