Epidemiology of Pseudomonas Aeruginosa in Cystic Fibrosis Patients in Iran: A Systematic Review and Meta-Analysis Pubmed



Foumani AA¹ ; Kalurazi TY² ; Rostami FM³ ; Ebrahimsaraie HS⁴ ; Nazarialam A⁵ ; Halaji M³
Source: Infezioni in Medicina Published:2020

Abstract

The present study aims to investigate the prevalence of Pseudomonas aeruginosa in Iranian Cystic Fibrosis (CF) patients. We conducted a systematic search on this topic in Web of Science, PubMed, Embase, Scop-us, and Google Scholar electronic databases to the end of July 2019. Then, 14 articles with eligible criteria were selected for data extraction and analysis by Comprehensive Meta-Analysis Software. The pooled prevalence of P. aeruginosa was 40.6% (95% CI: 32.4%-49.4%) ranging from 32.4% to 49.4%. There was a significant heterogeneity among the studies (χ2=21.02; p<0.001; I2 =86.07%). The funnel plot for publication bias showed no evi-dence of asymmetry. Based on the results of Begg’s and Egger’s test no significant publication bias was observed. The study demonstrated a relative prevalence of P. aeruginosa among CF patients in Iran. Due to the rapid spread and infection severity of P. aerugi-nosa and other opportunistic pathogens, efforts are required to identify risk factors, reservoirs, transmission routes and source of infection. © 2020, EDIMES Edizioni Medico Scientifiche. All rights reserved.