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Synthesis and Characterization of Cellulose Nanofibers/Chitosan/Cinnamon Extract Wound Dressing With Significant Antibacterial and Wound Healing Properties Publisher



Kefayat A1 ; Hamidi Farahani R1 ; Rafienia M2 ; Hazrati E3 ; Hosseini Yekta N4
Authors
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Authors Affiliations
  1. 1. Department of Infectious Diseases, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
  2. 2. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anesthesiology and Intensive Care, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
  4. 4. Department of Persian Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran

Source: Journal of the Iranian Chemical Society Published:2022


Abstract

Recently, bacterial cellulose-based wound dressings have gained lots of attention, and many studies have tried to improve the efficacy of these membranes with incorporation of different natural materials to fabricate an all-natural wound dressing with significant antibacterial and wound healing properties. In the present study, bacterial cellulose (BC) is produced from Gluconacetobacter xylinus to fabricate BC-based membranes. Then, chitosan (CS) and cinnamon extract (CE) are incorporated into the BC membranes to prepare an all-natural wound dressing. The obtained composite membrane (BC/CS/CE) is characterized according to chemical properties, surface morphology, mechanical properties, water absorptivity, water retention, CE release, antibacterial activity, biocompatibility, in vivo wound healing activity, and compared with BC and BC/CS membranes. The BC/CS/CE membrane is able to maintain appropriate moisture content for an acceptable period of time. Although the tensile strength and elongation at break values of the BC/CS/CE are slightly lower than the BC membrane, they are still in ideal ranges. The BC/CS/CE membrane exhibits significantly more antibacterial effects against Staphylococcus aureus and Escherichia coli in comparison with the BC and BC/CS which can be related to the sustained released profile of CE. In addition, BC/CS/CE is more biocompatible with L929 normal skin fibroblast cells in comparison with the BC and BC/CS membranes. Also, the BC/CS/CE membrane can meaningfully promote the wound healing progress compared with other membranes at the Wistar rats full-thickness skin wound model. The BC/CS/CE membrane-treated wounds have more developed dermis layer in comparison with other groups according to histopathological analyses. Taking together, the CS and CE enriched BC membranes can be a promising wound dressing with desirable properties. © 2021, Iranian Chemical Society.
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