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Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?



Hashemi M1 ; Taheri H1 ; Amiri N1 ; Yavari M1 ; Shaigannia I1 ; Moghadas L1 ; Talaee Z1 ; Shirzadi E1 ; Soleimani B1
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Authors Affiliations
  1. 1. Medical Students Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Acta Medica Iranica Published:2008

Abstract

Impaired fasting glucose identifies individuals at high risk of progression to diabetes but the role of IFG as a coronary artery disease risk factor, independent of its progression to diabetes and its association with other coronary artery disease risk factors ,is unclear. A cross-sectional study was conducted to evaluate the hypothesis that impaired fasting glucose increased the likelihood of atherosclerotic plaque formation. Blood chemistry data as well as traditional coronary artery disease risk factors from 812 patients referred for coronary angiography to heart centers in Shahid- Chamran and Sina hospital, Isfahan, Iran were recorded. The population were stratified into three groups according to American Diabetes Association criteria: normal fasting glucose (n=608), impaired fasting glucose(n=92) and diabetes mellitus(n=112). We use extent, Vessel and stenosis scores to indicate the coronary artery involvement. KrusKal-Wallis test showed that the means of extent, Vessel and stenosis scores are not significantly different between three groups(P> 0.05). Multivariate linear regression analysis, using extent score of coronary artery disease as dependent variable and traditional risk factors and impaired fasting glucose as independent variables did not show any significant difference either. Our data suggested that impaired fasting glucose is not associated with increased risk of coronary atherosclerosis. © 2008 Tehran University of Medical Sciences. All rights reserved.
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