Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Wound Healing by Topical Application of Antioxidant Iron Chelators: Kojic Acid and Deferiprone Publisher Pubmed



Mohammadpour M1 ; Behjati M2 ; Sadeghi A1 ; Fassihi A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Wound Journal Published:2013


Abstract

Kojic acid and deferiprone are iron chelators used for skin lightening and iron-overload treatment, respectively. As iron chelation and free radical scavenging are principal factors for wound healing, it was hypothesised that the local application of these compounds might accelerate wound healing in rats. Ointments of 3%, 6% and 9% of deferiprone and kojic acid were prepared and topical treatment was performed on in vivo wound models for 12 days twice in day for test and control groups. Topical treatment with 3%, 6% and 9% showed significant improvement in wound healing after 4 days (P < 0·001). Topical application of 3% and 6% deferiprone enhanced wound healing after 8 days (P < 0·026 and P < 0·001, respectively). Accelerated wound healing was seen using 3% and 6% deferiprone after 12 days (P = 0·003 and P < 0·001, respectively). DPPH scavenging assay was also performed to compare the antioxidant potencies of kojic acid and deferiprone. Deferiprone had more free radical scavenging power than kojic acid. Generally, deferiprone topical treatment, accelerated wound healing more than kojic acid because of its higher antioxidant and iron chelation abilities. © 2012 John Wiley & Sons Ltd and Medicalhelplines.com Inc.
Related Docs
View other Related Docs
1. The Effect of 2% Alcohol Green Tea Extract on Healing Process of Open Wound in Male Mice, Journal of Isfahan Medical School (2009)
2. The Effects of Nanoemulsion Cream Containing Lavender Essential Oil and Licorice Extract on Healing of Deep Skin Wound in Rats, Journal of Isfahan Medical School (2019)
3. A Comparison of the Effect of Certain Inorganic Salts on Suppression Acute Skin Irritation by Human Biometric Assay: A Randomized, Double-Blind Clinical Trial, Journal of Research in Medical Sciences (2016)
4. Wound Healing Effects of Quercus Brantii and Pelargonium Graveolens Extracts in Male Wistar Rats, Wounds (2016)
5. Wound Healing Activity of Pimpinella Anisum Methanolic Extract in Streptozotocin-Induced Diabetic Rats, Journal of Wound Care (2019)
6. Remedial Effect of Boswellia Serrata on Thermal Burn Injuries, Shiraz E Medical Journal (2015)
7. Effect of Green Tea (Camellia Sinensis) Extract on Healing Process of Surgical Wounds in Rat, International Journal of Surgery (2013)
8. A Promising Antibacterial Wound Dressing Made of Electrospun Poly (Glycerol Sebacate) (Pgs)/Gelatin With Local Delivery of Ascorbic Acid and Pantothenic Acid, Journal of Polymers and the Environment (2023)
Experts (# of related papers)
View all Related Experts
Valiollah Hajhashemi (4)
Mustafa Ghanadian (3)
Other Related Docs
9. All Trans Retinoic Acid Modulates Peripheral Nerve Fibroblasts Viability and Apoptosis, Tissue and Cell (2015)
10. Preparation and Characterization of an Antibacterial Cmc/Pcl Hydrogel Films Containing Cip/Cur: In Vitro and in Vivo Evaluation of Wound Healing Activity, International Journal of Biological Macromolecules (2024)
11. The Effect of Dressing With Fresh Kiwifruit on Burn Wound Healing, Surgery (2010)
12. Sa/G Hydrogel Containing Nrf2-Engineered Hek-293-Derived Cm Improves Wound Healing Efficacy of Wj-Mscs in a Rat Model of Excision Injury, Journal of Tissue Viability (2021)
13. Effects of Nanozeolite/Starch Thermoplastic Hydrogels on Wound Healing, Journal of Research in Medical Sciences (2017)
14. The Effect of Estrogen on Wound Healing in Rats, Pakistan Journal of Medical Sciences (2007)
15. The Effect of Dietary and Supplementation of Omega-3 and Omega-6 Fatty Acids on Healing of Skin, Gastrointestinal and Diabetic Wounds, Journal of Isfahan Medical School (2015)
16. Macroscopic Effect of Blue Light Cure on Wound Healing Process, Journal of Isfahan Medical School (2011)
17. Comparing the Wound Healing Effect of a Controlled Release Wound Dressing Containing Curcumin/Ciprofloxacin and Simvastatin/Ciprofloxacin in a Rat Model: A Preclinical Study, Journal of Biomedical Materials Research - Part A (2022)
18. The Effect of Vitamin a and Vitamin C on Postoperative Adhesion Formation: A Rat Model Study, Journal of Research in Medical Sciences (2014)
19. Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review, ACS Food Science and Technology (2022)
20. The Effect of Plantago Major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial, International Journal of Lower Extremity Wounds (2024)
21. Effect of a Selection of Skin Penetration Enhancers on Topical Anti-Inflammatory Effect of Boswellic Acids in Carrageenan-Induced Paw Edema in Rats, Advanced Biomedical Research (2021)
22. Wound Healing in Animal Models: Review Article, Tehran University Medical Journal (2017)
23. The Effects of Adiantum Capillus-Veneris on Wound Healing: An Experimental in Vitro Evaluation, International Journal of Preventive Medicine (2014)
24. Comparison the Effectiveness of Pyruvic Acid 50% and Salicylic Acid 30% in the Treatment of Acne, Journal of Research in Medical Sciences (2016)
25. Deep Skin Wound Healing Potential of Lavender Essential Oil and Licorice Extract in a Nanoemulsion Form: Biochemical, Histopathological and Gene Expression Evidences, Journal of Tissue Viability (2020)
26. Pistacia Atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat, Evidence-based Complementary and Alternative Medicine (2013)
27. Qsar Study of Antimicrobial 3-Hydroxypyridine-4-One and 3-Hydroxypyran-4-One Derivatives Using Different Chemometric Tools, International Journal of Molecular Sciences (2008)
28. The Anti-Inflammatory and Antipyretic Effects of Clove Oil in Healthy Dogs After Surgery, PharmaNutrition (2017)
29. Anti-Inflammatory and Wound Healing Activities of Aloe Littoralis in Rats, Research in Pharmaceutical Sciences (2012)
30. Potential Therapeutic Effects of Topical Recombinant Human Erythropoietin on Burn Wound Healing: A Preliminary Randomized Double-Blind Controlled Clinical Trial, Burns (2024)
31. Antimicrobial Activity and Wound Healing Effect of a Novel Natural Ointment: An in Vitro and in Vivo Study, Journal of Wound Care (2023)
32. In-Vivo Assessment of Application of Folinic Acid and Botulinum Toxin a in Cleft Lip Surgical Defects, Orthodontics and Craniofacial Research (2024)
33. The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats, Journal of Isfahan Medical School (2015)
34. Preventive Therapy of Experimental Colitis With Selected Iron Chelators and Anti-Oxidants, International Journal of Preventive Medicine (2012)
35. Efficacy of a Combination of Herbal Gel Versus Topical Diltiazem (2%) in Chronic Anal Fissure Healing: A Randomized Double-Blind Clinical Trial, Journal of HerbMed Pharmacology (2019)
36. Anti-Inflammatory and Analgesic Properties of the Leaf Extracts and Essential Oil of Lavandula Angustifolia Mill., Journal of Ethnopharmacology (2003)
37. Fabrication and Characterisation of Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded With Silver Nanoparticles and Sildenafil Citrate for Wound Dressing Applications, Materials Technology (2022)
38. Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia Carteri Vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-Degree Burn Wounds: A Randomized, Double-Blind Clinical Trial, Iranian Journal of Medical Sciences (2023)
39. Computer-Aided Design of Novel Antibacterial 3-Hydroxypyridine-4-Ones: Application of Qsar Methods Based on the Molmap Approach, Journal of Computer-Aided Molecular Design (2012)