Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Aqueous Concentrations of Vegf and Soluble Vegf Receptor-1 in Diabetic Retinopathy Patients



Javanmard SH1 ; Hasanpour Z1 ; Abbaspoor Z1 ; Naderian GA2 ; Jahanmard M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. AL Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2012

Abstract

Background: The aim of this study was to simultaneously measure the concentrations of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1, also known as sFlt-1) in the aqueous humor of patients with non-proliferative diabetic retinopathy (NPDR) and to investigate whether aqueous levels of vascular endothelial growth factor (VEGF) and VEGFR-1 are related to diabetic macular edema. Materials andMethods: Aqueous humor was collected from 27 diabetic patients and 33 age- and sex-matched normoglycemic controls and analyzed for pro-angiogenic VEGF and angiogenic inhibitor VEGFR-1 by enzyme-linked immunosorbent assay (ELISA).The mean foveal thickness was measured by optical coherence tomography (OCT). Results: There was no significant difference in the aqueous levels of VEGF in patients with NPDR compared with control subjects (P > 0.05), while the NPDR patients had significantly lower sVEGFR-1 in their aqueous humor. Furthermore, a significant (P < 0.01) positive correlation was observed between VEGF/sVEGFR-1 concentration and the mean foveal thickness measured on OCT. Conclusion: The results suggest that decreased chelating effect of sVEGFR-1 may be the preliminary event allowing VEGF to activate the proangiogenic endothelial cell state and to induce permeability. The imbalance between angiogenic agent (VEGF) and the antiangiogenic factors (sFlt-1), which is disturbed in the diabetic state, may determine the fate of diabetic macular edema.
Related Docs
View other Related Docs
1. Relationship Between Macular Thickness and the Ratio of Vascular Endothelial Growth Factor to Its Soluble Receptor 1 in Non-Proliferative Diabetic Retinopathy, Journal of Isfahan Medical School (2012)
2. Evaluation of Intravitreal Injection of Bevacizumab (Avastin) in Treatment of Diabetic Macular Edema, Journal of Research in Medical Sciences (2012)
3. Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Major Review, Survey of Ophthalmology (2024)
4. The Effect of Combination Therapy With Intravitreal Bevacizumab and Topical Timolol–Dorzolamide Eye Drops on Diabetic Macular Edema: A Double-Blind Randomized Controlled Trial, International Ophthalmology (2024)
5. The Additive Effect of Intravitreal Dexamethasone Combined With Bevacizumab in Refractory Diabetic Macular Edema; [L'effet Additif De La Dexamethasone Intravitreenne Associee Au Bevacizumab Dans L’Oedeme Maculaire Diabetique Refractaire], Journal Francais d'Ophtalmologie (2023)
6. Diabetic Retinopathy and Corneal Endothelial Parameters: An Analytical Cross-Sectional Study, BMC Ophthalmology (2022)
7. Multifocal Electroretinogram in Diabetic Macular Edema; Correlation With Visual Acuity and Optical Coherence Tomography, Journal of Ophthalmic and Vision Research (2015)
8. The Efficacy of Curcumin‑Piperine Supplementation in Patients With Nonproliferative Diabetic Retinopathy: An Optical Coherence Tomography Angiography‑Based Randomized Controlled Trial, Journal of Research in Medical Sciences (2024)
Experts (# of related papers)
View all Related Experts
Alireza Dehghani (8)
Heshmatollah Ghanbari (6)
Other Related Docs
9. Macular Optical Coherence Tomography Angiographic Study in Children With a History of Prematurity: A Systematic Review and Meta-Analysis, Current Eye Research (2025)
10. Comparison of Subthreshold Diode Laser Micropulse Therapy Versus Conventional Photocoagulation Laser Therapy As Primary Treatment of Diabetic Macular Edema, Journal of Current Ophthalmology (2016)
11. The Effect of Moderate-Intensity Aerobic Exercise on Non-Proliferative Diabetic Retinopathy in Type Ii Diabetes Mellitus Patients: A Clinical Trial, Microvascular Research (2023)
12. Orbital Doppler Evaluation of Blood Flow Velocities in Patients With Diabetic Retinopathy, Review of Diabetic Studies (2012)
13. Retinopathy in Newly Diagnosed Typ 2 Diabetec Patients in Isfahan, Prevalence and Risk Factors, Iranian Journal of Diabetes and Lipid Disorders (2006)
14. Phacoemulcification With Intravitreal Bevacizumab Injection in Patients With Cataract and Coexisting Diabetic Retinopathy: Prospective Randomized Study, Journal of Ocular Pharmacology and Therapeutics (2012)
15. Prevalence of Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Patients in Isfahan, Iran, Acta Endocrinologica (2008)
16. Comparison of the Effects of the Pattern Scan and Conventional Single Spot Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy; a Randomized Clinical Trial, Journal of Isfahan Medical School (2016)
17. Pan-Ppar Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats, International Journal of Peptides (2012)
18. Effect of Angiotensin Receptor Inhibitors on Endothelial Dysfunction Indices in Patients With Diabetic Nephropathy, Journal of Isfahan Medical School (2011)
19. Role of Fenofibrate in Restoring Angiogenesis in Diabetic and Control Hind Limb Ischemic Rats, General Physiology and Biophysics (2012)
20. Diabetic Retinopathy Clinical Practice Guidelines: Customized for Iranian Population, Journal of Ophthalmic and Vision Research (2016)
21. Effects of Subthreshold Diode Micropulse Laser Photocoagulation on Treating Patients With Refractory Diabetic Macular Edema, Journal of Current Ophthalmology (2019)
22. The Effect of Vitamin D Supplementation on the Outcome of Treatment With Bevacizumab in Diabetic Macular Edema: A Randomized Clinical Trial, International Ophthalmology (2022)
23. Baseline Subfoveal Choroidal Thickness As an Indicator for Bevacizumab Outcomes in Central Retinal Vein Occlusion, Tehran University Medical Journal (2019)
24. Incidence of and Risk Factors for Diabetic Retinopathy in Diabetic Clinic Attenders, Ophthalmic Epidemiology (2001)
25. Comparative Analysis of Optical Coherence Tomography Angiography (Octa) Results Between Behcet’S Disease Patients and a Healthy Control Group, Clinical Rheumatology (2024)
26. Prevalence, Incidence and Ecological Determinants of Diabetic Retinopathy in Iran: Systematic Review and Meta-Analysis, Journal of Ophthalmic and Vision Research (2019)
27. Application of Optical Coherence Tomography Angiography in True and Pseudo-Optic Disc Swelling, Journal of Ophthalmology (2024)
28. Combination of Intravitreal Bevacizumab and Topical Dorzolamide Versus Intravitreal Bevacizumab Alone for Diabetic Macular Edema: A Randomized Contralateral Clinical Trial, BioMed Research International (2020)
29. Imbalance of Angiogenesis in Diabetic Complications: The Mechanisms, International Journal of Preventive Medicine (2012)
30. Intravitreal Bevacizumab Versus Ranibizumab: Effects on the Vessels of the Fellow Non-Treated Eye, Journal of Current Ophthalmology (2019)
31. Green Tea and Its Anti-Angiogenesis Effects, Biomedicine and Pharmacotherapy (2017)
32. Nephrotoxicity Induced by Vascular Endothelial Growth Factor Inhibitors, Journal of Nephropharmacology (2022)
33. Automatic Detection of Microaneurysms in Oct Images Using Bag of Features, Computational and Mathematical Methods in Medicine (2022)
34. The Effect of Vitamin C on Endothelial Function of Children With Type 1 Diabetes: An Experimental Study, International Journal of Preventive Medicine (2014)
35. Rosiglitazone Enhances Neovascularization in Diabetic Rat Ischemic Hindlimb Model, Biomedical Papers (2012)
36. Ocular Delivery of Sunitinib-Loaded Nanoparticles Doped in Tragacanthic Acid Hydrogel in Treatment of Diabetic Retinopathy in Rats, Drug Development and Industrial Pharmacy (2022)
37. Comparison of the Effect of One and Three Sessions of Scatter Panretinal Photocoagulation (Prp) on the Improvement of Proliferative Diabetic Retinopathy, Journal of Isfahan Medical School (2019)
38. Intravitreal Fasudil Monotherapy for Treatment of Refractory Diabetic Macular Edema: A Prospective Interventional Case Series; [Monotherapie Intravitreenne Par Fasudil Pour Le Traitement De L’Oedeme Maculaire Diabetique Refractaire : Une Serie De Cas Interventionnels Prospectifs], Journal Francais d'Ophtalmologie (2023)
39. Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats, Journal of Isfahan Medical School (2012)
40. Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats, Journal of Isfahan Medical School (2012)
41. Incidence of and Risk Factors for Diabetic Retinopathy in Isfahan, Iran, Ophthalmic Epidemiology (2003)
42. The Effects of Folic Acid on Markers of Endothelial Function in Patients With Type 1 Diabetes Mellitus., Medicinski arhiv (2012)
43. The Effects of Blocking Angiotensin Receptors on Early Stages of Diabetic Nephropathy, International Journal of Preventive Medicine (2012)
44. Intravitreal Injections of Bevacizumab Plus Methotrexate Versus Bevacizumab Alone for the Treatment of Diabetic Macular Edema: A Randomized, Sham-Controlled Trial, Journal of Current Ophthalmology (2020)
45. Retinal Findings of Covid-19 Patients Using Ocular Coherence Tomography Angiography Two to Three Months After Infection: Ocular Appearance Recovered Covid-19 Patient, Photodiagnosis and Photodynamic Therapy (2022)
46. Intravitreal Diclofenac Plus Bevacizumab Versus Bevacizumab Alone in Treatment-Naive Diabetic Macular Edema: A Randomized Double-Blind Clinical Trial, International Ophthalmology (2017)
47. Effect of Captopril on Aqueous Levels of Angiotensin Ii and Its Correlation With Macular Edema in Diabetic Patients, Journal of Ophthalmic and Vision Research (2006)
48. The Effect of Curcumin-Piperine on Cardiometabolic, Inflammatory and Oxidative Stress Factors and Macular Vascular Density in Optical Coherence Tomography Angiography (Octa) in Patients With Non-Proliferative Diabetic Retinopathy: Study Protocol for a Randomized, Double-Blind Controlled Trial, Avicenna Journal of Phytomedicine (2023)
49. A Risk Score Development for Diabetic Retinopathy Screening in Isfahan-Iran, Journal of Research in Medical Sciences (2009)
50. Ganglion Cell Complex and Macular Thickness Layers in Primary Open-Angle Glaucoma, Pseudoexfoliation Glaucoma and Healthy Eyes: A Comparative Study, Photodiagnosis and Photodynamic Therapy (2021)