Effect of Probiotics on Oxidative Stress and Inflammatory Status in Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Clinical Trials Publisher



Bohlouli J¹ ; Namjoo I² ; Borzooisfahani M² ; Hojjati Kermani MA³ ; Balouch Zehi Z⁴ ; Moravejolahkami AR⁵
Source: Heliyon Published:2021

Abstract

This systematic review and meta-analysis was performed to evaluate the effect of probiotics on serum high sensitivity-C reactive protein (hs-CRP) and oxidative stress biomarkers among patients with Diabetic Nephropathy (DN). Electronic databases were searched through May 10, 2020. Seven trials that included 340 patients were identified for analysis. Meta-analysis indicated that probiotics significantly reduced hs-CRP (WMD = -1.53 mg/L; 95% CI = -2.38, -0.69; P < 0.001) and Malondialdehyde (MDA) (WMD = -0.62 hmol/L; 95% CI = -1.18, -0.06; P = 0.030) levels in DN patients, whereas they increased Glutathione (GSH) (WMD = 73.84 hmol/L; 95% CI = 24.3, 123.29; P = 0.003) and Total Antioxidant Capacity (TAC) (WMD = 26.54 mmol/L; 95% CI = 6.23, 46.85; P = 0.010). Therefore, probiotics may improve hs-CRP and oxidative stress biomarkers in DN population. © 2021 The Author(s); Probiotics; Oxidative Stress; C-Reactive Protein; Diabetic Nephropathies; Meta-Analysis © 2021 The Author(s)