Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Effects of Synbiotic Supplementation on Oxidative Stress Markers, Mental Status, and Quality of Life in Patients With Parkinson's Disease: A Double-Blind, Placebo-Controlled, Randomized Controlled Trial Publisher



Mehrabani S1 ; Khorvash F2 ; Heidari Z3 ; Tajabadiebrahimi M4 ; Amani R1
Authors

Source: Journal of Functional Foods Published:2023


Abstract

Researches show that the pathogenesis of Parkinson's disease (PD) is influenced by oxidative stress. This randomized controlled trial investigated the effect of 12 weeks of synbiotic supplementation on total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), glutathione (GSH), Malondialdehyde (MDA), Parkinson's disease quality of life (PDQ-39) and mental and fatigue status in PD patients. Synbiotic supplementation increased TAC (65.923 ± 208.347 nmol equivalent of Trolox/ml vs 5.642 ± 207.611 nmol equivalent of Trolox/ml, p = 0.023) and reduced MDA (−0.907 ± 2.154 nmol/ml vs +0.122 ± 2.518 nmol/ml, p < 0.001), and OSI (−0.187 ± 0.558 vs +0.017 ± 0.526, p = 0.001) compared with the control group. Depression decreased in the synbiotic compared with the control group. Well-being and cognitive impairment domains of PDQ-39 significantly improved while activities of daily living and PDQ-39 summary index marginally improved in the synbiotic compared with the control group. Synbiotic supplementation can be considered a complementary treatment for PD patients. In addition, further research is needed to replicate our findings. © 2022
Related Docs
View other Related Docs
1. The Effects of Synbiotic Supplementation on Oxidative Stress and Clinical Symptoms in Women With Migraine: A Double‐Blind, Placebo‐Controlled, Randomized Trial, Journal of Functional Foods (2021)
2. Prebiotics and Probiotics and Parkinson's Disease, Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders (2023)
3. Probiotics and the Treatment of Parkinson's Disease: An Update, Cellular and Molecular Neurobiology (2022)
Experts (# of related papers)
View all Related Experts
Hojatallah Alaei (4)
Gholamreza Askari (3)
Other Related Docs
4. The Effects of Synbiotic Supplementation on Fatigue Management and Mental Health Status in Levothyroxine-Treated Patients With Hypothyroidism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Study, Journal of Isfahan Medical School (2020)
5. The Effects of Mediterranean Diet on Severity of Disease and Serum Total Antioxidant Capacity (Tac) in Patients With Parkinson’S Disease: A Single Center, Randomized Controlled Trial, Nutritional Neuroscience (2022)
6. Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis, Molecular Neurobiology (2025)
7. The Oxidative Status and Na+/K+-Atpase Activity in Obsessive-Compulsive Disorder: A Case Control Study, BioMed Research International (2024)
8. Role of Dietary Antioxidants and Redox Status in Parkinson's Disease, Diet and Nutrition in Neurological Disorders (2023)
9. Association of Total Bilirubin With Motor Signs in Early Parkinson’S Disease in Lrrk2 Variant Carriers, Journal of Molecular Neuroscience (2022)
10. Can Berberine Serve As a New Therapy for Parkinson’S Disease?, Neurotoxicity Research (2022)
11. Effects of Crocin on Rotational Behavior, Lipid Peroxidation and Nitrite Levels in Rat’S Brain Striatum in an Experimental Model of Parkinson's Disease, Journal of Isfahan Medical School (2015)
12. Bio (6-Bromoindirubin-3′-Oxime) Gsk3 Inhibitor Induces Dopaminergic Differentiation of Human Immortalized Renvm Cells, Comparative Clinical Pathology (2018)
13. Effects of Preventive Treadmill Exercise on the Recovery of Metabolic and Mitochondrial Factors in the 6-Hydroxydopamine Rat Model of Parkinson’S Disease, Neurotoxicity Research (2019)
14. The Impact of Sesamol and Exercise on Striatal Tnf-Α Level, Motor Behavior, Aversive Memory and Oxidative Stress Status in 6-Hydroxydopamine-Lesioned Rats, Physiology and Pharmacology (Iran) (2022)
15. Assessment of Reliability and Validity of the Persian Version of the Parkinson’S Anxiety Scale (P-Pas), Applied Neuropsychology: Adult (2025)
16. A Report of the Iranian Parkinson’S Disease Registry, npj Parkinson's Disease (2025)
17. The Effects of Supplementation With Probiotic on Biomarkers of Oxidative Stress in Adult Subjects: A Systematic Review and Meta-Analysis of Randomized Trials, Probiotics and Antimicrobial Proteins (2020)
18. The Effects of Red Grape Juice and Exercise on Parkinson’S Disease in Male Rats, Journal of Isfahan Medical School (2012)
19. A Randomized, Double-Blind, Placebo-Controlled Parallel Trial to Test the Effect of Inulin Supplementation on Migraine Headache Characteristics, Quality of Life and Mental Health Symptoms in Women With Migraine, Food and Function (2024)
20. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)