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Probiotics and the Treatment of Parkinson's Disease: An Update Publisher Pubmed



Mirzaei H1 ; Sedighi S2 ; Kouchaki E3 ; Barati E4 ; Dadgostar E5 ; Aschner M6 ; Tamtaji OR1, 7
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Azad University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neurology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  7. 7. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular and Molecular Neurobiology Published:2022


Abstract

Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor and non-motor features. Although some progress has been made in conventional PD treatments, these breakthroughs have yet to show high efficacy in treating this neurodegenerative disease. Probiotics are live microorganisms that confer health benefits on the host when administered in adequate amounts. Probiotics have putative anticancer, antioxidative, anti-inflammatory, and neuroprotective effects. Multiple lines of evidence show that probiotics control and improve several motor and non-motor symptoms in patients and experimental animal models of PD. Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, as well as apoptosis. Herein, we summarize the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in PD. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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