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Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study Publisher Pubmed



Khodaie F1 ; Moghadasi AN1 ; Hosseinnataj A2 ; Baghbanian SM3 ; Ashtari F4 ; Razazian N5 ; Poursadeghfard M6 ; Majdinasab N7 ; Hatamian H8 ; Hoseini S9 ; Nahayati MA10 ; Nabavi SM11 ; Faraji F12 ; Harirchian MH13 Show All Authors
Authors
  1. Khodaie F1
  2. Moghadasi AN1
  3. Hosseinnataj A2
  4. Baghbanian SM3
  5. Ashtari F4
  6. Razazian N5
  7. Poursadeghfard M6
  8. Majdinasab N7
  9. Hatamian H8
  10. Hoseini S9
  11. Nahayati MA10
  12. Nabavi SM11
  13. Faraji F12
  14. Harirchian MH13
  15. Mir NHN14
  16. Moghadam NB15
  17. Sharifipour E16
  18. Bayati A17
  19. Kamali H18
  20. Mozhdehipanah H19
  21. Jalali N20
  22. Abotorabizarchi M21
  23. Kamyari N22
  24. Nikbakht R2
  25. Azimi A1
  26. Navardi S1
  27. Heidari H1
  28. Sahraian MA1
  29. Eskandarieh S1
Show Affiliations
Authors Affiliations
  1. 1. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biostatistics and Epidemiology, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Neurology, Booalicina Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Neurology, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. Department of Neurology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
  9. 9. Department of Neurology, School of Medicine, Neurosciences Research Center, Aging Research Institute, Imam Reza Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Regenerative Medicine, Royan Institute for Stem Cell Technology and Biology, Tehran, Iran
  12. 12. Department of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  13. 13. Department of Neurology, School of Medicine, Iranian Center of Neurological Research, Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  14. 14. Department of Internal Medicine, School of Medicine, Shohadaye Ashayer Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran
  15. 15. Department of Neurology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  16. 16. Department of Neurology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  17. 17. Department of Neurology, Shahrekord University of Medical Sciences and Health Services, Shahrekord, Iran
  18. 18. Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  19. 19. Department of Neurology, Qazvin University of Medical Sciences, Qazvin, Iran
  20. 20. Department of Neurology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  21. 21. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  22. 22. Department of Biostatistics and Epidemiology, School of Health, Abadan University of Medical Sciences, Abadan, Iran

Source: Clinical Neurology and Neurosurgery Published:2024


Abstract

Objective: The time to diagnosis of multiple sclerosis (MS) is of great importance for early treatment, thereby reducing the disability and burden of the disease. The purpose of this study was to determine the time from the onset of clinical symptoms to the diagnosis of MS and to evaluate the factors associated with a late diagnosis in Iranian MS patients. Methods: The present cross-sectional study was conducted on patients with MS who were registered in the National MS Registry System of Iran (NMSRI). Results: Overall, 23291 MS patients registered in 18 provinces of Iran were included in this study. The mean (standard deviation) interval between the onset of the disease and diagnosis of MS was 13.42 (32.40) months, and the median was one month. The diagnostic interval of 41.6% of patients was less than one month, and 14.8% of them had a one-month time to diagnosis. Patients with an age of onset below 18 years and those diagnosed after the age of 50 years had a longer time to diagnosis (P<0.001). Patients with primary progressive MS (PPMS) had the longest time to diagnose and those with relapsing-remitting MS (RRMS) had the shortest time (P<0.001). The results of negative binominal regression showed that the average rate of delay in diagnosis in women was 12% less than that in men. The average delay in diagnosis in patients with a positive family history of MS was 23% more than that in others. The rate of delay in the diagnosis of patients with PPMS and secondary progressive MS was 2.22 and 1.66 times higher, respectively, compared with RRMS. Conclusion: The findings of the present study revealed that more than half of the MS patients were diagnosed within a one-month interval from the symptom onset, which is an acceptable period. More attention should be paid to patients’ access to medical facilities and MS specialists. © 2024
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