Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Factors Affecting the Production of Nanostructure Lipid Carriers of Valproic Acid Publisher Pubmed



Varshosaz J1 ; Eskandari S1 ; Kennedy R2 ; Tabbakhian M1 ; Minaiyan M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, 81745-359, Iran
  2. 2. School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, 2678, Australia
  3. 3. Department of Pharmacology, School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, 81745-359, Iran

Source: Journal of Biomedical Nanotechnology Published:2013


Abstract

The objective of this study was to optimize a nano-lipid carrier (NLCs) of valproic acid for nasal delivery using statistical methods. NLCs were prepared by solvent diffusion method followed by ultrasonication. After a preliminary screening study using Taguchi design, the Box-Behnken statistical model using desirability function was applied to evaluate variables affecting key specifications (minimum particle size, maximum drug loading and optimum release) of nano-lipid carriers of valproic acid. Each variable was assessed at three levels of surfactant concentration, acetone/ethanol volume ratio and organic/aqueous phase volume ratio. The best predicted model for particle size and drug release was quadratic model, while for drug loading, 2 factor interaction model fitted better. The measured results for the optimized formulation were a mean size of 154 nm, 47% payload and 75% of drug content released within 21 days. The optimum formulation was obtained using 1% of Poloxamer-188 as surfactant, organic/aqueous phase volume ratio of 1/5 and acetone/ethanol volume ratio of 3/1. Overall, the results show that entrapment of valproic acid in nano-lipid carriers was achieved. Such carriers might be a promising delivery system in the treatment of seizures via the nasal route of administration. Copyright © 2013 American Scientific Publishers All rights reserved.
Related Docs
View other Related Docs
1. Production and Optimization of Valproic Acid Nanostructured Lipid Carriers by the Taguchi Design, Pharmaceutical Development and Technology (2010)
2. Nanostructured Lipid Carriers (Nlc): A Potential Delivery System for Bioactive Food Molecules, Innovative Food Science and Emerging Technologies (2013)
3. Formulation and Optimization of Solid Lipid Nanoparticle Formulation for Pulmonary Delivery of Budesonide Using Taguchi and Box-Behnken Design, Research in Pharmaceutical Sciences (2015)
4. Brain Delivery of Valproic Acid Via Intranasal Administration of Nanostructured Lipid Carriers: In Vivo Pharmacodynamic Studies Using Rat Electroshock Model., International journal of nanomedicine (2011)
5. Hesperetin-Loaded Solid Lipid Nanoparticles and Nanostructure Lipid Carriers for Food Fortification: Preparation, Characterization, and Modeling, Food and Bioprocess Technology (2013)
6. Enhancement of Oral Bioavailability of Pentoxifylline by Solid Lipid Nanoparticles, Journal of Liposome Research (2010)
7. Formulation and Optimization of Solid Lipid Nanoparticles of Buspirone Hcl for Enhancement of Its Oral Bioavailability, Journal of Liposome Research (2010)
8. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (42)
Jaber Emami Baferani (13)
Other Related Docs
9. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
10. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)
11. Targeting Etoposide to Acute Myelogenous Leukaemia Cells Using Nanostructured Lipid Carriers Coated With Transferrin, Nanotechnology (2012)
12. Optimization of Freeze-Drying Condition of Amikacin Solid Lipid Nanoparticles Using D-Optimal Experimental Design, Pharmaceutical Development and Technology (2012)
13. In-Vitro and In-Vivo Evaluation of Chitosanbased Thermosensitive Gel Containing Lorazepam Nlcs for the Treatment of Status Epilepticus, IET Nanobiotechnology (2020)
14. Biological Safety Evaluation of Stealth Solid Lipid Nanoparticles of Risperidone: Effect of Surface Characteristics on Their Hydrophobicity, Haemolysis and Macrophage Phagocytosis, Farmacia (2012)
15. Freeze-Drying of Nanostructure Lipid Carriers by Different Carbohydrate Polymers Used As Cryoprotectants, Carbohydrate Polymers (2012)
16. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and in Vitro Characterization, Journal of Nanomaterials (2014)
17. Preparation and Evaluation of a New Salbutamol Fast-Dissolving Oral Film for Asthma Treatment, Journal of Isfahan Medical School (2013)
18. Biodistribution of Amikacin Solid Lipid Nanoparticles After Pulmonary Delivery, BioMed Research International (2013)
19. In Vitro - in Vivo Relationships: Concepts, Regulatory Perspectives, Advances and Attempts, Journal of Pharmacy and Pharmaceutical Sciences (2006)
20. Characterization of Drug Release and Diffusion Mechanism Through Hydroxyethylmethacrylate/Methacrylic Acid Ph-Sensitive Hydrogel, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2004)
21. Efavirenz Oral Delivery Via Lipid Nanocapsules: Formulation, Optimisation, and Ex-Vivo Gut Permeation Study, IET Nanobiotechnology (2018)
22. Optimization of a Single-Chain Antibody Fragment Overexpression in Escherichia Coli Using Response Surface Methodology, Research in Pharmaceutical Sciences (2015)
23. Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization, Journal of Dispersion Science and Technology (2012)
24. Development of Dry Powder Inhaler Containing Tadalafil-Loaded Plga Nanoparticles, Research in Pharmaceutical Sciences (2017)
25. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
26. Optimization of Anti-Cxcl10 Nanobody Expression Using Response Surface Methodology and Evaluation of Its Anti-Metastatic Effect on Breast Cancer Cells, International Journal of Peptide Research and Therapeutics (2020)
27. 5Fu-Loaded Pcl/Chitosan/Fe3o4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System, Advanced Pharmaceutical Bulletin (2022)
28. Nasal Delivery of Insulin Using Bioadhesive Chitosan Gels, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
29. Design, Formulation and Physicochemical Evaluation of Acetaminophen Effervescent Tablets, Journal of Reports in Pharmaceutical Sciences (2013)
30. How Do Various Encapsulation Techniques Improve the Oral Delivery of Food Protein Hydrolysates?, Food Frontiers (2025)
31. Pharmaceutical Evaluation of Atorvastatin-Loaded Nanostructured Lipid Carriers Incorporated Into the Gelatin/Hyaluronic Acid/Polycaprolactone Scaffold for the Skin Tissue Engineering, Journal of Biomaterials Applications (2021)
32. Effects of Thermal Processing and Ph on the Physicochemical Properties, Stability, and Structure of Taxifolin-Loaded Nanostructured Lipid Carriers, Applied Food Research (2024)
33. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
34. Edta and Α-Tocopherol Improve the Chemical Stability of Astaxanthin Loaded Into Nanostructured Lipid Carriers, European Journal of Lipid Science and Technology (2014)
35. In Vitro-In Vivo Correlation: From Theory to Applications, Journal of Pharmacy and Pharmaceutical Sciences (2006)
36. The Effect of Formulation Variables on the Characteristics of Insulin-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres Prepared by a Single Phase Oil in Oil Solvent Evaporation Method, Colloids and Surfaces B: Biointerfaces (2009)
37. Stability and Antimicrobial Effect of Amikacin-Loaded Solid Lipid Nanoparticles, International Journal of Nanomedicine (2011)
38. Folate Targeted Solid Lipid Nanoparticles of Simvastatin for Enhanced Cytotoxic Effects of Doxorubicin in Chronic Myeloid Leukemia, Current Nanoscience (2012)
39. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
40. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
41. Targeted Nanostructured Lipid Carrier for Brain Delivery of Artemisinin: Design, Preparation, Characterization, Optimization and Cell Toxicity, Journal of Pharmacy and Pharmaceutical Sciences (2018)
42. Design and Characterization of Astaxanthin-Loaded Nanostructured Lipid Carriers, Innovative Food Science and Emerging Technologies (2014)
43. Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation, Journal of Dispersion Science and Technology (2012)
44. Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded With Bupropion Hcl by a D-Optimal Design, BioMed Research International (2015)
45. Comparing the Drug Loading and Release of Silica Aerogel and Pva Nano Fibers, Journal of Non-Crystalline Solids (2019)
46. Effect of Carrier Morphology and Surface Characteristics on the Development of Respirable Plga Microcapsules for Sustained-Release Pulmonary Delivery of Insulin, International Journal of Pharmaceutics (2010)
47. Galactosylated Nanostructured Lipid Carriers for Delivery of 5-Fu to Hepatocellular Carcinoma, Journal of Liposome Research (2012)
48. Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules, Recent Patents on Nanotechnology (2021)
49. Β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, in Vitro Simulated Digestion and Hypocholesterolemic Activity, Pharmaceutics (2020)
50. Pulmonary Delivery of Docetaxel and Celecoxib by Plga Porous Microparticles for Their Synergistic Effects Against Lung Cancer, Anti-Cancer Agents in Medicinal Chemistry (2022)