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Herbal Medicines As Potential Inhibitors of Sars-Cov-2 Infection Publisher Pubmed



Rostami S1 ; Gharibi S2 ; Yaghoobi H3 ; Nokhodian Z4 ; Shoaei P1 ; Bahrami AA5 ; Ahangarzadeh S4 ; Alibakhshi A6
Authors
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Authors Affiliations
  1. 1. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Core Research Facilities (CRF), Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Current Pharmaceutical Design Published:2022


Abstract

Coronavirus disease 2019 (COVID-19) is the result of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding molecular pathogenesis is an essential factor for the allocation of effective preventive measures and the development of targeted therapeutics against COVID-19. The genome of SARS-CoV-2 encodes structural and nonstructural proteins, which can be targets for compounds with potential therapeutic ability. On the other hand, the virus life cycle has stages susceptible to targeting by drug compounds. Many natural antiviral compounds have been studied and evaluated at the cellular and molecular levels with antiviral potential. Meanwhile, many studies over the past few months have shown that plant polysaccharides have a good ability to target proteins and stages of the virus life cycle. In this regard, in this review study, the virus specifications and infectious process and structural and functional components of SARS-CoV-2 will be reviewed, and then the latest studies on the effect of plant compounds with more focus on polysaccharides on viral targets and their inhibitory potential on the infectious process of COVID-19 will be discussed. © 2022 Bentham Science Publishers.
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