Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Role of Vitamin C in Vanadyl-Sulfate-Induced Nephrotoxicity and Hepatotoxicity



Mahdianrad A1 ; Mazaheri S2 ; Nematbakhsh M3 ; Talebi A4 ; Baradaran A5
Authors

Source: Journal of Isfahan Medical School Published:2016

Abstract

Background: Vanadium (V) is a candidate to decrease the serum level of glucose in diabetic animal model. However, it affects the lipid peroxidation and antioxidant activity so could make nephrotoxicity and hepatotoxicity. In this study, the protective role of vitamin C as an antioxidant on nephrotoxicity and hepatotoxicity induced by vanadyl sulfate was investigated. Methods: This study was designed in 2 protocols. There were 3 groups in protocol 1 that received saline (group 1), saline daily for 7 days plus single dose of vanadyl sulfate (50 mg/kg intraperitoneally) in day 2 (group 2), or vitamin C (250 mg/kg intraperitoneally) daily for 7 days and single dose of vanadyl sulfate (group 3). There were 2 groups in protocol 2 that received saline plus single dose of vanadyl sulfate (50 mg/kg intraperitoneally) in day 2 (group 4) or vitamin C (250 mg/kg intraperitoneally) daily for 2 days plus single dose of vanadyl sulfate (group 5). At the end of experiment, blood samples were collected to measure serum level of blood urea nitrogen (BUN), creatinine (Cr), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), and all animals were sacrificed for histopathology investigation and determination of kidney tissue damage score (KTDS). Findings: In protocol 1, BUN/Cr ratio, kidney weight (KW), and KTDS decreased significantly in vanadyl sulfate plus vitamin C group in comparison with vanadyl sulfate plus saline group (P < 0.05). In addition, serum level of AST and ALP significantly decreased in vanadyl sulfate plus vitamin C group. In protocol 2, not only similar results were not observed, but also vitamin C increased the side effects of vanadyl sulfate. Conclusion: Administration of vitamin C as a potent antioxidant could decrease the vanadium-induced toxicity. So, as vanadyl sulfate can be used for diabetic model in laboratory, vitamin C can be useful to decrease the vanadium-induced nephrotoxicity and hepatotoxicity, too. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Low Doses of Vanadyl Sulfate Protect Rats From Lipid Peroxidation and Hypertriglyceridemic Effects of Fructose-Enriched Diet, International Journal of Diabetes and Metabolism (2006)
2. Thymoquinone Mitigates Diclofenac-Induced Hepatorenal Toxicity in Male Wistar Rats by Balancing the Redox State and Modulating Bax/Bcl-2/Caspase-3 Apoptotic Pathways and Nf-Κb Signaling, Research in Pharmaceutical Sciences (2025)
3. Vitamin E in the Prevention of Vancomycin-Induced Nephrotoxicity, Research in Pharmaceutical Sciences (2020)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (4)
Ardeshir Talebi (3)
Other Related Docs
4. Vanadyl Sulfate Ameliorates Insulin Resistance and Restores Plasma Dehydroepiandrosterone-Sulfate Levels in Fructose-Fed, Insulin-Resistant Rats, Clinical Biochemistry (2004)
5. Effect of Hydroalcoholic and Buthanolic Extract of Cucumis Sativus Seeds on Blood Glucose Level of Normal and Streptozotocin-Induced Diabetic Rats, Iranian Journal of Basic Medical Sciences (2011)
6. Effect of the Administration of Solanum Nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats, Pharmacognosy Research (2017)
7. Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences, Asian Pacific Journal of Cancer Prevention (2017)
8. Antihyperglycemic and Antihyperlipidemic Effect of Chronic Administration of Hesperetin in Diabetic Rats, Journal of Babol University of Medical Sciences (2010)
9. Comparative Study of Nephroprotective Effects of Resveratrol and Silymarin in Diabetic Rats; an Experimental Histopathologic Study, Journal of Nephropharmacology (2024)
10. Pretreatment Effect of D-Limonene on Oxidative Stress Induced by Renal Ischemia-Reperfusion Injury in Rats, Journal of Babol University of Medical Sciences (2022)
11. The Effect of 2,3-Dihydroxybenzoic Acid and Tempol in Prevention of Vancomycin-Induced Nephrotoxicity in Rats, Toxicology (2007)
12. Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits, Drugs under Experimental and Clinical Research (2005)
13. The Protective Effect of Lycopene Supplement Against Vancomycin-Induced Nephrotoxicity; a Randomized Double-Blind Placebo-Controlled Clinical Trial, Journal of Renal Injury Prevention (2020)
14. Effect of Short Hydration on Cisplatin-Induced Nephrotoxicity in Cancer Patients: A Retrospective Study, International Journal of Hematology-Oncology and Stem Cell Research (2017)
15. Antioxidant Activity of Three Extracts of Morus Nigra, Phytotherapy Research (2004)
16. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant Against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model, International Journal of Nephrology (2012)
17. Effect of Vitamin C Supplementation on Oxidative Stress and Lipid Profiles in Hemodialysis Patients, International Journal for Vitamin and Nutrition Research (2009)
18. Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat, Iranian Biomedical Journal (2003)
19. Gender Differences in Response to Vitamin E and C in Gentamicin Induced Nephrotoxicity in Wistar Rats, Journal of Nephropathology (2017)
20. Inflammatory Biomarkers, Antioxidant Enzyme Activities, and Oxidative Stress in Iranian Male Patients With Type 2 Diabetes Mellitus: Effects of Eicosapentaenoic Acid and Vitamin C Supplementation, Journal of Research in Medical Sciences (2012)