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Pentacyclic Triterpenes in Euphorbia Microsciadia With Their T-Cell Proliferation Activity



Ayatollahi AM1, 6 ; Ghanadian M2 ; Afsharypour S2 ; Abdella OM3 ; Mirzai M4 ; Askari G5
Authors

Source: Iranian Journal of Pharmaceutical Research Published:2011

Abstract

The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass fragmentation pattern, nuclear magnetic resonance (NMR) data and their biologic immunomodulatory effects. The structures of the isolated compounds were elucidated by 13C- and1H-NMR as well as 2D-NMR, IR and by the aid of mass fragmentation pattern and comparing with the literature. After running T-Cell proliferation assay, oleanolic acid stimulated proliferation of T-Cells at lower concentration 0.5 μg/mL, while betulinic acid and ursolic acid showed inhibitory activity against T-Cell proliferation with IC50- value > 50 μg/mL and 3.01 ± 0.47 μg/mL, respectively. © 2011 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.
2. Biological Screening of Euphorbia Aellenii, Iranian Journal of Pharmaceutical Research (2010)
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