Can Icam and Vcam Can Predict Severity of Cad in Stable Angina?



Montazeri N¹ ; Sadeghi M² ; Sanei H¹ ; Asgary S³ ; Farjoallahi M⁴ ; Akbari M⁵ ; Akhbari MR¹ ; Teimouri S⁶
Source: Journal of Isfahan Medical School Published:2009

Abstract

Background: Ischemic heart disease is the leading cause of mortality and morbidity in the world. Vascular inflammation is the noticeable risk factors of ischemic heart disease. In this study the relation between intracellular adhesion molecule (ICAM) and vascular adhesion molecule (VCAM) as inflammation indicator with extent of coronary involvement were evaluated. Methods: In this cross sectional study, 82 patients with stable angina who candidates for angiography were studied. Those with acute coronary syndrome, and recent surgery, inflammatory disease, some drug consumption, kidney and liver disease, Phlebitis and PTE are excluding from study. Then blood sampling for biochemical VCAM and ICAM analysis were drawn. After it, coronary angiography was done via standard method. Findings: Mean ages of the patients were 58.4 ± 10.1 year old with 72% male. The mean of ICAM and VCAM were 183.9 ± 78 and 150.3 ± 136 ng/dl, respectively. There isn’t any correlation between VCAM and ICAM and the severity of coronary artery disease. In linear regression analysis even with considering of hypertension, hyperlipidemia and diabetes as cofounders, there was not any relation between these factors and CAD. Conclusion: According to our findings, inflammatory markers (VCAM and ICAM) didn’t add any further information about extent of CAD. © 2009, Isfahan University of Medical Sciences(IUMS). All rights reserved.