Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Keratin-Containing Scaffolds for Tissue Engineering Applications: A Review Publisher Pubmed



Soleymani Eil Bakhtiari S1 ; Karbasi S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  2. 2. Biomaterials and Tissue Engineering Department, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Biomaterials Science, Polymer Edition Published:2024


Abstract

In tissue engineering and regenerative medicine applications, the utilization of bioactive materials has become a routine tool. The goal of tissue engineering is to create new organs and tissues by combining cell biology, materials science, reactor engineering, and clinical research. As part of the growth pattern for primary cells in an organ, backing material is frequently used as a supporting material. A porous three-dimensional (3D) scaffold can provide cells with optimal conditions for proliferating, migrating, differentiating, and functioning as a framework. Optimizing the scaffolds’ structure and altering their surface may improve cell adhesion and proliferation. A keratin-based biomaterials platform has been developed as a result of discoveries made over the past century in the extraction, purification, and characterization of keratin proteins from hair and wool fibers. Biocompatibility, biodegradability, intrinsic biological activity, and cellular binding motifs make keratin an attractive biomaterial for tissue engineering scaffolds. Scaffolds for tissue engineering have been developed from extracted keratin proteins because of their capacity to self-assemble and polymerize into intricate 3D structures. In this review article, applications of keratin-based scaffolds in different tissues including bone, skin, nerve, and vascular are explained based on common methods of fabrication such as electrospinning, freeze-drying process, and sponge replication method. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Investigating of Physical, Mechanical, and Biological Properties of Polyhydroxybutyrate-Keratin/Alumina Electrospun Scaffold Utilized in Bone Tissue Engineering, Materials Chemistry and Physics (2023)
2. Nano/Micro-Formulations of Keratin in Biocomposites, Wound Healing and Drug Delivery Systems; Recent Advances in Biomedical Applications, European Polymer Journal (2022)
3. Biological Evaluation and Osteogenic Potential of Polyhydroxybutyrate-Keratin/Al2o3 Electrospun Nanocomposite Scaffold: A Novel Bone Regeneration Construct, International Journal of Biological Macromolecules (2023)
4. Evaluation of the Effects of Zein Incorporation on Physical, Mechanical, and Biological Properties of Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
5. Modified Poly(3-Hydroxybutyrate)-Based Scaffolds in Tissue Engineering Applications: A Review, International Journal of Biological Macromolecules (2021)
6. Evaluation of the Effects of Decellularized Umbilical Cord Wharton's Jelly Ecm on Polyhydroxy Butyrate Electrospun Scaffolds: A New Strategy for Cartilage Tissue Engineering, Materials Today Chemistry (2024)
7. Evaluation of the Effects of Decellularized Extracellular Matrix Nanoparticles Incorporation on the Polyhydroxybutyrate/Nano Chitosan Electrospun Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2024)
8. Fabrication and Characterization of Novel Polyhydroxybutyrate-Keratin/Nanohydroxyapatite Electrospun Fibers for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (86)
Mohammad Rafienia (43)
Other Related Docs
9. Chitosan/Mwcnts Nanocomposite Coating on 3D Printed Scaffold of Poly 3-Hydroxybutyrate/Magnetic Mesoporous Bioactive Glass: A New Approach for Bone Regeneration, International Journal of Biological Macromolecules (2024)
10. Evaluation of the Effects of Decellularized Wharton Jelly Nanoparticles on Polyhydroxy Butyrate-Chitosan Electrospun Scaffolds for Cartilage Tissue Engineering Applications, Journal of Polymers and the Environment (2025)
11. Evaluation of the Effects of Cartilage Decellularized Ecm in Optimizing Phb-Chitosan-Hnt/Chitosan-Ecm Core-Shell Electrospun Scaffold: Physicochemical and Biological Properties, Biomaterials Advances (2025)
12. Electrospun Halloysite Nanotube Loaded Polyhydroxybutyrate-Starch Fibers for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
13. Evaluation of the Effects of Keratin on Physical, Mechanical and Biological Properties of Poly (3-Hydroxybutyrate) Electrospun Scaffold: Potential Application in Bone Tissue Engineering, European Polymer Journal (2020)
14. Evaluation of the Effects of Glucosamine Sulfate on Poly(3- Hydroxybutyrate) -Chitosan/Carbon Nanotubes Electrospun Scaffold for Cartilage Tissue Engineering Applications, Polymer-Plastics Technology and Materials (2022)
15. Uio-66 Metal-Organic Framework (Mof) As an Osteogenic Stimulant in the Poly-3-Hydroxybutyrate-Zein/Uio-66 Electrospun Composite Scaffold for Bone Tissue Engineering Applications, Journal of Polymers and the Environment (2025)
16. Evaluation of the Effects of Halloysite Nanotubes on Physical, Mechanical, and Biological Properties of Polyhydroxy Butyrate Electrospun Scaffold for Cartilage Tissue Engineering Applications, Journal of Polymers and the Environment (2024)
17. A Core-Shell Electrospun Scaffold of Polyhydroxybutyrate-Starch/Halloysite Nanotubes Containing Extracellular Matrix and Chitosan for Articular Cartilage Tissue Engineering Application, Journal of Polymers and the Environment (2023)
18. Recent Innovations in Strategies for Breast Cancer Therapy by Electrospun Scaffolds: A Review, Journal of Polymers and the Environment (2024)
19. Evaluating the Osteogenic Properties of Polyhydroxybutyrate-Zein/Multiwalled Carbon Nanotubes (Mwcnts) Electrospun Composite Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2024)
20. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
21. Ultra-Thin Electrospun Nanocomposite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Magnetic Mesoporous Bioactive Glasses for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2024)
22. Polyhydroxybutyrate-Starch/Carbon Nanotube Electrospun Nanocomposite: A Highly Potential Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
23. Effects of Decellularized Extracellular Matrix on Polyhydroxybutyrate Electrospun Scaffolds for Cartilage Tissue Engineering, Polymer-Plastics Technology and Materials (2023)
24. Recent Advances in Electrospun Protein Fibers/Nanofibers for the Food and Biomedical Applications, Advances in Colloid and Interface Science (2023)
25. Osteogenic Potential of Phb-Lignin/Cellulose Nanofiber Electrospun Scaffold As a Novel Bone Regeneration Construct, International Journal of Biological Macromolecules (2023)
26. Evaluation of the Effects of Halloysite Nanotube on Polyhydroxybutyrate - Chitosan Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
27. Synthetic-Based Blended Electrospun Scaffolds in Tissue Engineering Applications, Journal of Materials Science (2022)
28. Using of Keratin Substrate for Enrichment of Ht29 Colorectal Cancer Stem-Like Cells, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2019)
29. Poly(Methyl Methacrylate)-Based Composite Bone Cements With Different Types of Reinforcement Agents, Encyclopedia of Materials: Composites (2021)
30. Investigation of Physical, Mechanical and Biological Properties of Polyhydroxybutyrate-Chitosan/Graphene Oxide Nanocomposite Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
31. Baghdadite/Polycaprolactone Nanocomposite Scaffolds: Preparation, Characterisation, and in Vitro Biological Responses of Human Osteoblast-Like Cells (Saos-2 Cell Line), Materials Technology (2020)
32. Biodegradation and Cellular Evaluation of Aligned and Random Poly (3-Hydroxybutyrate)/Chitosan Electrospun Scaffold for Nerve Tissue Engineering Applications, Materials Technology (2020)
33. Effect of Cellulose Nanofibers on Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
34. Mupirocin Loaded Core-Shell Pluronic-Pectin-Keratin Nanofibers Improve Human Keratinocytes Behavior, Angiogenic Activity and Wound Healing, International Journal of Biological Macromolecules (2023)
35. Chondrogenesis of Mesenchymal Stromal Cells on the 3D Printed Polycaprolactone/Fibrin/Decellular Cartilage Matrix Hybrid Scaffolds in the Presence of Piascledine, Journal of Biomaterials Science, Polymer Edition (2024)
36. Evaluation of Physical and Mechanical Properties of Fi-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nanocomposite Scaffold for Bone Tissue Engineering Application, Scientia Iranica (2017)
37. Hybrid Nano-Micro Scaffolds for Cartilage Tissue Engineering: Integrating Pcl-Dwjm-Mwcnts on Chemically Modified Silk Fibroin, Journal of Polymers and the Environment (2025)
38. Biomimetic Vegf-Loaded Bilayer Scaffold Fabricated by 3D Printing and Electrospinning Techniques for Skin Regeneration, Materials and Design (2024)
39. Evaluation of Physical, Mechanical and Biological Properties of Bioglass/Titania Scaffold Coated With Poly (3-Hydroxybutyrate)-Chitosan for Bone Tissue Engineering Applications, Materials Technology (2020)
40. Evaluation of Physical, Mechanical and Biological Properties of Β-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nano Composite Scaffold for Bone Tissue Engineering Application, Materials Technology (2021)
41. Chemofunctionalization of Knitted Silk to Improve Interface Connection in a Nano/Micro Scaffold Based on Polycaprolactone-Chitosan-Multi-Walled Carbon Nanotube/Silk, International Journal of Biological Macromolecules (2024)
42. Natural and Synthetic Polymeric Scaffolds Used in Peripheral Nerve Tissue Engineering: Advantages and Disadvantages, Polymers for Advanced Technologies (2021)
43. Electrospun Polyurethane-Gelatin Composite: A New Tissue-Engineered Scaffold for Application in Skin Regeneration and Repair of Complex Wounds, ACS Biomaterials Science and Engineering (2020)
44. Fabrication and Evaluation of Cs/Pvp Sponge Containing Platelet-Rich Fibrin As a Wound Healing Accelerator: An in Vitro and in Vivo Study, International Journal of Biological Macromolecules (2022)
45. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
46. Physical, Mechanical, and Biological Performance of Chitosan-Based Nanocomposite Coating Deposited on the Polycaprolactone-Based 3D Printed Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
47. Plasma Surface Modification of Electrospun Polyhydroxybutyrate (Phb) Nanofibers to Investigate Their Performance in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
48. Physical, Mechanical and Biological Performance of Phb-Chitosan/Mwcnts Nanocomposite Coating Deposited on Bioglass Based Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2020)
49. Poly Glycerol Sebacate/ Polycaprolactone/ Carbon Quantum Dots Fibrous Scaffold As a Multifunctional Platform for Cardiac Tissue Engineering, Materials Chemistry and Physics (2021)
50. Potential of an Electrospun Composite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Alumina Nanowires in Bone Tissue Engineering Applications, Materials Science and Engineering C (2019)