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Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues Publisher Pubmed



Sadeghi A1, 2 ; Niknam M3 ; Momenimoghaddam MA4 ; Shabani M5 ; Aria H6, 7 ; Bastin A8 ; Teimouri M9 ; Meshkani R5 ; Akbari H1, 2
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  7. 7. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Clinical Research Development Center “The Persian Gulf Martyrs” Hospital, Bushehr University of Medical Sciences, Bushehr, Iran
  9. 9. Department of Biochemistry, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran

Source: European Journal of Medical Research Published:2023


Abstract

Insulin is a critical hormone that promotes energy storage in various tissues, as well as anabolic functions. Insulin resistance significantly reduces these responses, resulting in pathological conditions, such as obesity and type 2 diabetes mellitus (T2DM). The management of insulin resistance requires better knowledge of its pathophysiological mechanisms to prevent secondary complications, such as cardiovascular diseases (CVDs). Recent evidence regarding the etiological mechanisms behind insulin resistance emphasizes the role of energy imbalance and neurohormonal dysregulation, both of which are closely regulated by autophagy. Autophagy is a conserved process that maintains homeostasis in cells. Accordingly, autophagy abnormalities have been linked to a variety of metabolic disorders, including insulin resistance, T2DM, obesity, and CVDs. Thus, there may be a link between autophagy and insulin resistance. Therefore, the interaction between autophagy and insulin function will be examined in this review, particularly in insulin-responsive tissues, such as adipose tissue, liver, and skeletal muscle. © 2023, BioMed Central Ltd., part of Springer Nature.
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