Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Preparation and Characterization of Poly (Lactic-Co-Glycolic Acid) Nanofibers Containing Simvastatin Coated With Hyaluronic Acid for Using in Periodontal Tissue Engineering Publisher Pubmed



Malekpour Z1 ; Akbari V2 ; Varshosaz J1 ; Taheri A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmaceutical Biotechnology and Isfahan Pharmaceutical Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Biotechnology Progress Published:2021


Abstract

Periodontal diseases can lead to soft tissue defects. Tissue engineering can provide functional replacements for damaged tissues. Recently, electrospun nanofibers have attracted great interest for tissue engineering and drug delivery applications. This has been revealed that statins exhibit positive impacts on the proliferation and regeneration of periodontal tissues. Electrospun simvastatin loaded poly (lactic-co-glycolic acid) (SIM-PLGA-NF) were prepared using electrospinning technique. Optimal conditions for preparation of SIM-PLGA-NF (PLGA concentration of 30 wt%, voltage of 15 kV, and flow rate of 1.5 ml h−1) were identified using a 23 factorial design. The optimized SIM-PLGA-NFs (diameter of 640.2 ± 32.5 nm and simvastatin entrapment efficacy of 99.6 ± 1.5%) were surface modified with 1% w/v hyaluronic acid solution (1%HA- SIM-PLGA-NF) to improve their compatibility with fibroblasts and potential application as a periodontal tissue engineering scaffold. HA-SIM-PLGA NFs were analyzed using SEM, FTIR, and XRD. 1%HA-SIM-PLGA-NF had uniform, bead-free and interwoven morphology, which is similar to the extracellular matrix. The mechanical performance of SIM-PLGA-NFs and release profile of simvastatin from these nanofibers have been also greatly improved after coating with HA. In vitro cellular tests showed that the proliferation, adhesion, and differentiation of fibroblast cells positively enhanced on the surface of 1%HA- SIM-PLGA-NF. These results demonstrate the potential application of 1%HA-SIM-PLGA-NFs as a scaffold for periodontal tissue engineering. © 2021 American Institute of Chemical Engineers.
Related Docs
View other Related Docs
1. Synthetic-Based Blended Electrospun Scaffolds in Tissue Engineering Applications, Journal of Materials Science (2022)
2. Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells, Journal of Biomaterials Science, Polymer Edition (2022)
3. Electrospun Aligned Plga and Plga/Gelatin Nanofibers Embedded With Silica Nanoparticles for Tissue Engineering, International Journal of Biological Macromolecules (2015)
4. An in Vitro and in Vivo Study of Pcl/Chitosan Electrospun Mat on Polyurethane/Propolis Foam As a Bilayer Wound Dressing, Biomaterials Advances (2022)
5. Recent Trends in the Application of Protein Electrospun Fibers for Loading Food Bioactive Compounds, Food Chemistry: X (2023)
6. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
7. Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review, Materials (2020)
8. Scaffold Percolative Efficiency: In Vitro Evaluation of the Structural Criterion for Electrospun Mats, Journal of Materials Science: Materials in Medicine (2010)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (55)
Mohammad Rafienia (33)
Other Related Docs
9. Preparation and Evaluation of Poly Glycerol Sebacate/Poly Hydroxy Butyrate Core-Shell Electrospun Nanofibers With Sequentially Release of Ciprofloxacin and Simvastatin in Wound Dressings, Polymers for Advanced Technologies (2018)
10. Incorporation of Mesoporous Silica Nanoparticles Into Random Electrospun Plga and Plga/Gelatin Nanofibrous Scaffolds Enhances Mechanical and Cell Proliferation Properties, Materials Science and Engineering C (2016)
11. Comparison of Physical, Mechanical and Biological Effects of Leucocyte-Prf and Advanced-Prf on Polyacrylamide Nanofiber Wound Dressings: In Vitro and in Vivo Evaluations, Biomaterials Advances (2022)
12. Enhanced Wound Regeneration by Pgs/Pla Fiber Dressing Containing Platelet-Rich Plasma: An in Vitro Study, Scientific Reports (2024)
13. Recent Advances in Modification Strategies of Pre- and Post-Electrospinning of Nanofiber Scaffolds in Tissue Engineering, Reactive and Functional Polymers (2022)
14. Preparation and Evaluation of Bioactive Bilayer Composite Membrane Phb/Β-Tcp With Ciprofloxacin and Vitamin D3 Delivery for Regenerative Damaged Tissue in Periodontal Disease, Journal of Applied Polymer Science (2022)
15. Fabrication and Characterization of Metformin-Loaded Plga/Collagen Nanofibers for Modulation of Macrophage Polarization for Tissue Engineering and Regenerative Medicine, BMC Biotechnology (2023)
16. Improvement of Endothelial Cell Performance in an Optimized Electrospun Pre-Polyglycerol Sebacate-Poly Lactic Acid Scaffold for Reconstruction of Intima in Coronary Arteries, Journal of Polymers and the Environment (2020)
17. The Effects of Statins on Dental and Oral Health: A Review of Preclinical and Clinical Studies, Journal of Translational Medicine (2020)
18. In Vitro Comparison Study of Plasma Treated Bilayer Pgs/Pcl and Pgs/Pla Scaffolds for Vascular Tissue Engineering, Fibers and Polymers (2022)
19. Montelukast Incorporated Poly(Methyl Vinyl Ether-Co-Maleic Acid)/Poly(Lactic-Co-Glycolic Acid) Electrospun Nanofibers for Wound Dressing, Fibers and Polymers (2017)
20. Adipose-Derived Stem Cells Growth and Proliferation Enhancement Using Poly (Lactic-Co-Glycolic Acid) (Plga)/Fibrin Nanofiber Mats, Journal of Applied Biotechnology Reports (2021)
21. Fabrication of Gehlenite Nanopowder Containing Electrospun Nanofibers for Bone Tissue Engineering, Fibers and Polymers (2021)
22. In Vitro Hemocompatibility and Cytocompatibility of a Three-Layered Vascular Scaffold Fabricated by Sequential Electrospinning of Pcl, Collagen, and Plla Nanofibers, Journal of Biomaterials Applications (2016)
23. Synthesis of Polyurethane/Hyaluronic Acid/Royal Jelly Electrospun Scaffold and Evaluating Its Properties for Wound Healing, Journal of Mazandaran University of Medical Sciences (2021)
24. Needleless Electrospinning, Electrospun and Nanofibrous Membranes: Principles and Applications (2022)
25. Incorporating Fingolimod Through Poly(Lactic-Co-Glycolic Acid) Nanoparticles in Electrospun Polyurethane/Polycaprolactone/Gelatin Scaffold: An in Vitro Study for Nerve Tissue Engineering, Polymers for Advanced Technologies (2022)
26. Plasma Surface Modification of Electrospun Polyhydroxybutyrate (Phb) Nanofibers to Investigate Their Performance in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
27. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
28. Nano/Micro Hybrid Scaffold of Pcl or P3hb Nanofibers Combined With Silk Fibroin for Tendon and Ligament Tissue Engineering, Journal of Applied Biomaterials and Functional Materials (2015)
29. Fabrication and Characterization of Chitosan-Gelatin/Single-Walled Carbon Nanotubes Electrospun Composite Scaffolds for Cartilage Tissue Engineering Applications, Polymers for Advanced Technologies (2022)
30. A Novel Flexible, Conductive, and Three-Dimensional Reduced Graphene Oxide/Polyurethane Scaffold for Cell Attachment and Bone Regeneration, Materials and Design (2022)
31. Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
32. Preparation of Fibrin/Poly Vinyl Alcohol Electrospun Nanofibers Scaffold for Tissue Engineering Applications, Journal of Isfahan Medical School (2016)
33. 3D Printed Polylactic Acid-Based Nanocomposite Scaffold Stuffed With Microporous Simvastatin-Loaded Polyelectrolyte for Craniofacial Reconstruction, International Journal of Biological Macromolecules (2024)
34. Blood Compatibility and Cell Response Improvement of Poly Glycerol Sebacate/Poly Lactic Acid Scaffold for Vascular Graft Applications, Journal of Biomedical Materials Research - Part A (2021)
35. In Vivo Integration of Poly(E-Caprolactone)/Gelatin Nanofibrous Nerve Guide Seeded With Teeth Derived Stem Cells for Peripheral Nerve Regeneration, Journal of Biomedical Materials Research - Part A (2014)
36. Biological Evaluation and Osteogenic Potential of Polyhydroxybutyrate-Keratin/Al2o3 Electrospun Nanocomposite Scaffold: A Novel Bone Regeneration Construct, International Journal of Biological Macromolecules (2023)
37. Characterization and Biological Evaluation of New Plga/Fibrin/Lignin Biocomposite Electrospun Scaffolds, Physica Scripta (2023)
38. Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs, Polymers (2022)
39. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
40. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
41. Evaluation of the Effects of Chitosan Nanoparticles on Polyhydroxy Butyrate Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
42. Implementing Taguchi Method to Analyze Electrospinning Parameters Influence on Mg-Doped Fluorapatite Nanoparticles-Poly (Ε-Caprolactone) Nanocomposite Scaffold (Mg-Fa Nps/Pcl) Properties, Polymers for Advanced Technologies (2020)
43. Polycaprolactone-Chitosan/Multi-Walled Carbon Nanotube: A Highly Strengthened Electrospun Nanocomposite Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
44. In Vivo and in Vitro Evaluation of Poly (Lactide-Co-Glycolide)/Bioactive Glass Nanocomposite Coating, Advanced Materials Research (2014)
45. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
46. Evaluation of the Effects of Zein Incorporation on Physical, Mechanical, and Biological Properties of Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
47. Physical and Biological Properties of Blend-Electrospun Polycaprolactone/Chitosan-Based Wound Dressings Loaded With N-Decyl-N, N-Dimethyl-1-Decanaminium Chloride: An in Vitro and in Vivo Study, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2020)
48. Effect of Polyhydroxybutyrate/Chitosan/Bioglass Nanofiber Scaffold on Proliferation and Differentiation of Stem Cells From Human Exfoliated Deciduous Teeth Into Odontoblast-Like Cells, Materials Science and Engineering C (2018)
49. Platelet Rich Fibrin Containing Nanofibrous Dressing for Wound Healing Application: Fabrication, Characterization and Biological Evaluations, Materials Science and Engineering C (2021)
50. A Novel Wound Dressing Nanofiber With Anti-Inflammatory and Anti-Bacterial Drugs Release for Skin Wound Healing, Journal of Isfahan Medical School (2019)