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A Double-Layer Cellulose/Pectin-Soy Protein Isolate-Pomegranate Peel Extract Micro/Nanofiber Dressing for Acceleration of Wound Healing Publisher Pubmed



Mirhaj M1, 2 ; Varshosaz J3 ; Nasab PM1 ; Almusawi MH4 ; Almajidi YQ5 ; Shahriarikhalaji M6 ; Tavakoli M1, 2 ; Alizadeh M7 ; Sharifianjazi F8 ; Mehrjoo M9, 10 ; Labbaf S2 ; Sattar M11 ; Esfahani SN12
Authors
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Authors Affiliations
  1. 1. Pharmacy Student's Research Committee, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  3. 3. Novel Drug Delivery Systems Research Centre, Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
  5. 5. Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq
  6. 6. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China
  7. 7. Department of Biomedical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
  8. 8. Department of Natural Sciences, School of Science and Technology, University of Georgia, Tbilisi, 0171, Georgia
  9. 9. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  10. 10. Iran National Cell Bank, Pasteur Institute of Iran, Tehran, Iran
  11. 11. College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Shanghai, 201620, China
  12. 12. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Biological Macromolecules Published:2024


Abstract

Multi-layered wound dressings can closely mimic the hierarchical structure of the skin. Herein, a double-layer dressing material is fabricated through electrospinning, comprised of a nanofibrous structure as a healing-support layer or the bottom layer (BL) containing pectin (Pec), soy protein isolate (SPI), pomegranate peel extract (P), and a cellulose (Cel) microfiber layer as a protective/monitoring layer or top layer (TL). The formation of a fine bilayer structure was confirmed using scanning electron microscopy. Cel/Pec-SPI-P dressing showed a 60.05 % weight loss during 7 days of immersion in phosphate buffered solution. The ultimate tensile strength, elastic modulus, and elongation at break for different dressings were within the range of 3.14–3.57 MPa, 32.26–36.58 MPa, and 59.04–63.19 %, respectively. The release of SPI and phenolic compounds from dressings were measured and their antibacterial activity was evaluated. The fabricated dressing was non-cytotoxic following exposure to human keratinocyte cells. The Cel/Pec-SPI-P dressing exhibited excellent cell adhesion and migration as well as angiogenesis. More importantly, in vivo experiments on Cel/Pec-SPI-P dressings showed faster epidermal layer formation, blood vessel generation, collagen deposition, and a faster wound healing rate. Overall, it is anticipated that the Cel/Pec-SPI-P bilayer dressing facilitates wound treatment and can be a promising approach for clinical use. © 2023
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